Avecort, ointment 0.1% 15 g

Pharmacodynamics

Mometasone furoate is a synthetic glucocorticosteroid (GCS) for topical use. It has anti-inflammatory, antipruritic and anti-exudative effects.

The GKS induce the release of phospholipase Ai inhibitory proteins, collectively known as lipocortins, which control the biosynthesis of inflammatory mediators such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.

Pharmacokinetics

The absorption of the drug Avecort ointment for external use is negligible. Eight hours after application on intact skin (without an occlusive dressing) about 0.7% of the steroid is detected in the systemic bloodstream.

Indications

Active ingredient

Composition

Per 100 g:

active ingredient:

mometasone furoate – 0.1 g;

excipients:

Vaseline – 77.9 g,

propylene glycol – 12.0 g,

emulsion wax – 5.0 g,

Purified water – 3.0 g,

Glyceryl monostearate – 2.0 g,

Phosphoric acid to pH 3.0-7.5.

How to take, the dosage

Interaction

Special Instructions

Influence of the drug Avecort ointment for external use on the ability to drive vehicles and mechanisms

No effect of the drug Avecort ointment for external use on the ability to drive or move machinery has been noted.

Contraindications

Side effects

Classification of the frequency of side effects according to the recommendations of the World Health Organization (WHO): Very common >1/10; common >1/100 to <1/10; infrequent >1/1000 to <1/100; rare >1/10000 to <1/1000; very rare <1/10000, including individual reports; frequency is unknown – it is impossible to determine the incidence from the available data.

Infectious and parasitic diseases:
rarely, folliculitis, secondary infection.

Skin and subcutaneous tissue disorders:

Rarely – skin irritation, dry skin, burning sensation of the skin, itching, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, skin atrophy, stretch marks, sweat, papule and pustule formation.

Nervous system disorders:

Frequency unknown – paresthesias.

When external forms of GCS are used for prolonged periods and/or when applied to large areas of skin, or with the use of occlusive dressings, especially in children and adolescents, side effects characteristic of systemic GCS may occur, including adrenal insufficiency and Itzenko-Cushing’s syndrome.

Overdose

Pregnancy use

Similarities