Atifin, cream 1% 15 g
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Atifin is an antifungal drug for external use with a broad spectrum of antifungal activity.
In low concentrations, terbinafine shows fungicidal activity against dermatophytes: Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporam canis, Epidermophyton floccosum; certain dimorphic fungi: Pityrosporam orbiculare; molds: mainly Candida albicans. Activity against yeast fungi, depending on their species, may be fungicidal or fungistatic.
Due to the inhibition by terbinafine of the enzyme squaleneepoxidase located on the cell membrane of the fungus, the early stage of sterol biosynthesis in fungi changes in a specific way: ergosterol deficiency and intracellular squalene accumulation lead to cell death of the fungus.
Terbinafine has no effect on cytochrome P450 isoenzymes in humans and, therefore, on the metabolism of hormones or other drugs.
Pharmacokinetics
The absorption of terbinafine hydrochloride <5% when the drug is applied externally.
It has a slight systemic effect.
Indications
Active ingredient
Composition
1 g of cream for external use contains:
The active ingredient:
terbinafine hydrochloride – 10 mg.
Auxiliary substances:
sodium hydroxide;
benzyl alcohol;
sorbitan stearate;
cetyl palmitate;
cetyl alcohol;
stearyl alcohol;
polysorbate 60;
isopropyl myristate;
distilled water.
How to take, the dosage
Interaction
There are no known drug interactions for terbinafine in cream form.
Special Instructions
A reduction in clinical manifestations is usually seen in the first days of treatment. If treatment is intermittent or stopped prematurely, there is a risk of recurrence of the infection.
Atifin cream is for external use only. Avoid getting it in the eyes, irritation may occur. If the drug accidentally gets into the eyes, they should be rinsed immediately with running water, and if persistent irritation develops, consult a doctor. If allergic reactions develop, the drug should be discontinued.
Contraindications
With caution: hepatic and/or renal insufficiency, alcoholism, suppression of medullary hematopoiesis, tumors, metabolic diseases, vascular occlusive disease of the extremities, children under 12 years (lack of sufficient clinical experience).
Side effects
Redness, itching or burning sensation may occur where the product is applied.
Allergic reactions.
Overdose
Pregnancy use
Terbinafine has not been shown to have teratogenic properties in experimental studies. To date, no malformations have been reported with Atifin. However, since clinical experience with the drug in pregnant women is very limited, it should be used only under strict indications.
Terbinafine is excreted with the breast milk. However, when Atifin cream is used by a nursing mother, a small amount of the active substance is absorbed through the skin, so adverse effects on the baby are unlikely.
Similarities
Weight | 0.029 kg |
---|---|
Shelf life | 2 years |
Conditions of storage | At a temperature not exceeding 25 °C |
Manufacturer | KRKA dd Novo mesto, Slovenia |
Medication form | exterior cream |
Brand | KRKA dd Novo mesto |
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