Asterisk Flu powder, 15 g 10 pcs.

Combined drug.

Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, the synthesis of steroid hormones, increases resistance to infection, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid.

It improves the tolerability of paracetamol and prolongs its effects (associated with prolongation of T1/2).

Paracetamol is a non-narcotic analgesic, acting on the centers of pain and thermoregulation, has analgesic and antipyretic effects. Pheniramine is a blocker of H1-histamine receptors, reduces rhinorrhea and lacrimation, eliminates spastic phenomena.

Phenylephrine is an adrenomimetic with moderate vasoconstrictor action (stimulation of alpha1-adrenoreceptors).

Indications

Active ingredient

Composition

Active substances:

Paracetamol 325 mg;

pheniramine maleate 20 mg;

phenylephrine hydrochloride 10 mg;

ascorbic acid 50 mg;

Auxiliary substances:

povidone 25 mg,

mannitol 2 g,

calcium phosphate 30 mg,

sucrose 11.29 g,

citric acid 1 g,

sodium citrate 100 mg,

aspartame 10 mg,

raspberry flavoring 140 mg.

How to take, the dosage

Internal. Dissolve the contents of one sachet in 1 cup of boiled hot water.

Drink while hot. It is possible to add sugar to taste.

Repeat doses may be taken every 4 hours (no more than 4 doses in 24 hours).

Stellar Flu can be used at any time of the day.

If there is no relief of symptoms within days of starting the drug, a doctor should be consulted.

Interaction

It enhances the effects of MAO inhibitors, sedative drugs, ethanol.

Ethanol increases the sedative effect of pheniramine contained in the drug. Pheniramine together with MAO inhibitors, furazolidone may lead to hypertensive crisis, agitation, hyperpyrexia.

Antidepressants, antiparkinsonian and antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation. Glucocorticosteroids (GCS) increase the risk of increased intraocular pressure.

Paracetamol reduces the effectiveness of uricosuric drugs and increases the effectiveness of indirect anticoagulants. Tricyclic antidepressants increase sympathomimetic effects, concomitant administration of halothane increases the risk of ventricular arrhythmia.

Decreases the hypotensive effect of guanethidine, which in turn increases the alpha-adrenergic stimulating activity of phenylephrine.

Special Instructions

During the treatment it is necessary to refrain from using ethanol (possible development of hepatotoxic effect).

Impact on the ability to drive and operate machinery

Do not drive motor transport and engage in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

– hypersensitivity to the components of the drug;

– childhood under 12 years of age;

– phenylketonuria;

– diabetes mellitus;

– portal hypertension;

– alcoholism;

– renal insufficiency;

– glucose-6-phosphate dehydrogenase deficiency;

– concomitant use of tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), beta-adrenoblockers.

Side effects

Allergic reactions (skin rash, itching, urticaria, angioedema), nausea, epigastric pain; anemia, thrombocytopenia, agranulocytosis.

Excited excitability, dizziness, increased blood pressure, disturbance of falling asleep. Midriasis, accommodation paresis, increased intraocular pressure, dry mouth; urinary retention.

In long-term use in high doses – hepatotoxic effects, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia; nephrotoxicity (renal colic, glucosuria, interstitial nephritis, papillary necrosis).

Overdose

Symptoms (caused by paracetamol): pallor of the skin, decreased appetite, nausea, vomiting; hepatonecrosis (severity of necrosis due to intoxication directly depends on the degree of overdose).

The toxic effect in adults is possible after the use of more than 10-15 g of paracetamol: increase of liver transaminases activity, increase of prothrombin time (12-48 hours after the use); the full clinical picture of liver damage is seen in 1-6 days.

Rarely liver failure develops lightning-fast and may be complicated by renal failure (tubular necrosis). Treatment: administration of SH-group donators and precursors of glutathione synthesis – methionine in 8-9 hours after overdose and N-acetylcysteine in 12 hours.

The need for additional therapeutic measures (further administration of methionine, intravenous N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Similarities