Ascorbic acid, 50 mg/ml 2 ml 10 pcs

Ascorbic acid replenishes vitamin C deficiency.

It forms ascorbic acid – dehydroascorbic acid system which participates in hydrogen transfer and regulates the reduction of a number of metabolites and monooxygenase system activity.

Indications

Composition

How to take, the dosage

Therapeutic doses for adults when administered parenterally are 1-3 ml of 5% solution (2-6 ml of 2.5% solution) per day. Children are administered parenterally 1-2 ml of 5% solution (2-4 ml of 2.5% solution) per day.

The course of treatment depends on the nature and course of the disease.

Interaction

Pharmaceutically incompatible with aminophylline, bleomycin, cefazolin, cefapirin, chlordiazepoxide, estrogens, dextrans, doxapram, erythromycin, methicillin, nafcillin, benzylpenicillin, warfarin.

Enhances blood concentrations of benzylpenicillin and tetracyclines; at a dose of 1 g / day increases the bioavailability of ethinylestradiol (including those included in oral contraceptives). Reduces the effectiveness of heparin and indirect anticoagulants.

Concomitant use with acetylsalicylic acid increases urinary excretion of ascorbic acid and decreases excretion of acetylsalicylic acid.

Induces the risk of crystalluria during treatment with short-acting salicylates and sulfonamides, slows renal excretion of acids, increases excretion of drugs with an alkaline reaction (including alkaloids), reduces the blood concentration of oral contraceptives. Increases total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Drugs of the quinoline series, calcium preparations, salicylates, glucocorticosteroids with long-term use deplete ascorbic acid reserves.

In concomitant use reduces the chronotropic effect of isoprenaline.

In long-term use or use in high doses may prevent the interaction of disulfiram and ethanol. In high doses increases excretion of mexiletine by the kidneys. Barbiturates and primidone increase ascorbic acid excretion with urine.

Decreases therapeutic effects of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubal reabsorption of amphetamine and tricyclic antidepressants.

Special Instructions

Because of the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, adrenal function and blood pressure should be monitored. High doses of ascorbic acid increase oxalate excretion, contributing to the formation of kidney stones. Newborns whose mothers have taken high doses of ascorbic acid and adults who have taken high doses may experience “ricochet” scurvy. Prolonged use of high doses may suppress pancreatic insular function, so it should be regularly monitored during treatment. In patients with high iron content in the body ascorbic acid should be used in minimal doses. As a reducing agent ascorbic acid may distort the results of various laboratory tests (blood and urine content of glucose, bilirubin, activity of “liver” transaminases and lactate dehydrogenase).

Impact on driving and operating machinery

At the time of treatment, caution should be exercised while driving motor transport and engaging in potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity, with long-term use in high doses (more than 500 mg) – diabetes mellitus, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency.

With caution

Sideroblastic anemia, urolithiasis.

Overdose

Symptoms: nephrolithiasis, insomnia, irritability, hypoglycemia.

Treatment: symptomatic, forced diuresis.