Ascorbic acid, 50 mg/ml 1 ml 10 pcs

Ascorbic acid has pronounced restorative properties and is involved in the regulation of carbohydrate metabolism, redox processes, blood coagulation, normalization of capillary permeability, tissue regeneration, synthesis of steroid hormones, collagen, procollagen.

Indications

Used for preventive and therapeutic purposes in all clinical situations involving the need for supplemental administration of vitamin C.

. It is indicated for the prevention and treatment of scurvy, bleeding (nasal, pulmonary, uterine, caused by radiation sickness), hemorrhagic diathesis, various intoxications and infectious diseases, nephropathy of pregnant women, Addison’s disease, overdose of anticoagulants, bone fractures and lax healing wounds, various dystrophies, increased mental stress and increased physical labor.

Composition

Active ingredient:

ascorbic acid 50 mg.

Excipients:

Sodium bicarbonate (sodium bicarbonate),

Sodium sulfite (sodium sulfate) 2 mg,

Injection water saturated with carbon dioxide to 1 ml.

How to take, the dosage

It is used as prescribed by the doctor.

Ascorbic acid is prescribed intramuscularly or intravenously.

The course of treatment depends on the nature and course of the disease.

Interaction

Pharmaceutically incompatible with aminophylline, bleomycin, cefazolin, cefapirin, chlordiazepoxide, estrogens, dextrans, doxapram, erythromycin, methicillin, nafcillin, benzylpenicillin, warfarin.

Enhances blood concentrations of benzylpenicillin and tetracyclines; at a dose of 1 g / day increases the bioavailability of ethinylestradiol (including those included in oral contraceptives). Reduces the effectiveness of heparin and indirect anticoagulants.

Concomitant use with acetylsalicylic acid increases urinary excretion of ascorbic acid and decreases excretion of acetylsalicylic acid.

Induces the risk of crystalluria during treatment with short-acting salicylates and sulfonamides, slows renal excretion of acids, increases excretion of drugs with an alkaline reaction (including alkaloids), reduces the blood concentration of oral contraceptives. Increases total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Drugs of the quinoline series, calcium preparations, salicylates, glucocorticosteroids with long-term use deplete ascorbic acid reserves.

In concomitant use reduces the chronotropic effect of isoprenaline.

In long-term use or use in high doses may prevent the interaction of disulfiram and ethanol. In high doses increases excretion of mexiletine by the kidneys. Barbiturates and primidone increase ascorbic acid excretion with urine.

Decreases therapeutic effects of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubal reabsorption of amphetamine and tricyclic antidepressants.

Special Instructions

Because of the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, adrenal function and blood pressure should be monitored. High doses of ascorbic acid increase oxalate excretion, contributing to kidney stone formation.

In newborns whose mothers have taken high doses of ascorbic acid and in adults who have taken high doses, “ricochet” scurvy can occur.

In prolonged use of high doses it is possible suppression of pancreatic insular apparatus function, so it should be regularly monitored during treatment.

In patients with elevated iron content in the body ascorbic acid should be used in minimal doses. As a reducing agent, ascorbic acid may distort the results of various laboratory tests (blood and urine content of glucose, bilirubin, activity of “hepatic” transaminases and lactate dehydrogenase).

Impact on driving and operating machinery

At the time of treatment, caution should be exercised while driving motor transport and engaging in potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity, with long-term use in high doses (more than 500 mg) – diabetes mellitus, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency.

With caution

Sideroblastic anemia, urolithiasis.

Pregnancy and lactation use

Pregnancy and lactation use only if the estimated benefit to the mother exceeds the potential risk to the fetus and child. The minimum daily requirement of ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to the high doses of ascorbic acid taken by the pregnant woman, and then the newborn may develop “withdrawal” syndrome. The minimum daily requirement during lactation is 80 mg.

A mother’s diet containing an adequate amount of ascorbic acid is sufficient to prevent its deficiency in the infant. Theoretically, there is a danger to the baby when the mother uses high doses of ascorbic acid (it is recommended not to exceed the breastfeeding mother’s daily requirement of ascorbic acid).

Overdose

Symptoms: nephrolithiasis, insomnia, irritability, hypoglycemia.

Treatment: symptomatic, forced diuresis.