Artroker, 50 mg capsules 100 pcs

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A nonsteroidal anti-inflammatory agent.

Pharmic action:

Anthraquinoline derivative, a diacetylated derivative of Rein. Metabolized to the active metabolite – Rein, it inhibits the activity of interleukin-1, which plays an important role in the development of inflammation and cartilage degradation in osteoarthritis.
Inhibits the action of other cytokines (including interleukin-6, TNF-alpha). The action develops in 2-4 weeks.

Pharmacokinetics:

Highly absorbed from the gastrointestinal tract, bioavailability is increased by 25% when taken with food.

TCmax is 144 min. Cmax is 3.15 mg/l with a single use of 50 mg, Cmax is increased with multiple use due to drug cumulation. It is completely deacetylated to reine. Rein’s binding to proteins (albumin) is almost 100%. Rein penetrates through the placental and blood-brain barrier.

The T1/2 is 255 min. It is excreted by the kidneys unchanged (20%), as glucuronide (60%), as sulfate – 20%.

Indications

Primary and secondary osteoarthritis.

Active ingredient

Composition

1 capsule contains:

Active ingredient:

Diacerein 50.0 mg

Associates:

Lactose monohydrate,

povidone,

croscarmellose sodium,

sodium lauryl sulfate,

magnesium stearate,

colloidal silicon dioxide

The hard gelatin capsule (housing):

gelatin, water, diamond blue dye, titanium dioxide, floxin B dye, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium lauryl sulfate

The hard gelatin capsule (cap):

gelatin, water, diamond blue dye, titanium dioxide, quinoline yellow dye, floxin B dye, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium lauryl sulfate

How to take, the dosage

The standard intake is 1 capsule 2 times a day (morning and evening, after a meal). Capsules should be swallowed whole, without chewing, and drink water. The effect of the treatment should be expected in 2-4 weeks.

Artroker is used continuously for a long time or for courses of at least 4 months.

The length of the break between courses of treatment is determined by the doctor.

Interaction

Artroker is not recommended to be taken together with drugs that affect the consistency of intestinal contents (e.g., large amounts of fiber).

Antacids reduce absorption of the drug.

The incidence of intestinal adverse events may increase if concomitantly taken with antibiotics or chemotherapeutic drugs that affect the intestinal microflora.

Special Instructions

The duration of treatment can be long depending on the result achieved. In the period preceding the development of therapeutic effect, Artroker can be taken simultaneously with non-narcotic analgesics and other non-steroidal anti-inflammatory drugs.

Periodic monitoring of blood values, activity of liver enzymes, urine is necessary.

In case of deterioration of renal function the physician should decide to reduce the dose of the drug or cancel it.

Contraindications

Individual intolerance to the components of the drug Artroker or high sensitivity to anthraquinone preparations (e.g., laxatives).
Childhood age (under 18 years).
Pregnancy, lactation period.
Severe hepatic or renal insufficiency, intestinal obstruction, inflammatory bowel diseases.
Lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
With caution:
Patients with lower intestinal irritation the drug is prescribed only in special cases.

Side effects

In case of hypersensitivity to the drug components, allergic reactions of varying degrees, rash, itching may occur.

In the initial period of taking the drug, digestive system disorders may occur temporarily: diarrhea, nausea, vomiting, abdominal pain. In this case the dose should be reduced to 1 capsule a day.

There may be intense yellow to brown staining of urine (depending on pH), which does not require reducing the dose (withdrawal) of the drug.

Overdose

In case of overdose, diarrhea and weakness may occur. In case of overdose or accidental ingestion by children it is necessary to consult a doctor.

The treatment is symptomatic.

Similarities