Artradol, lyophilizate 100 mg 10 pcs

Pharmaceutical group:

Pharmaceutical regulating metabolism in cartilage.

Pharmaceutical action:

Chondroitin sulfate is the main component of proteoglycans that together with collagen fibers make up the cartilage matrix.
It has chondroprotective properties, inhibits the activity of enzymes that cause degradation of articular cartilage, stimulates chondrocytes to produce proteoglycans, increases metabolic processes in cartilage and subchondral bone, affects calcium-phosphorus metabolism in cartilage tissue, stimulates its regeneration, and participates in the formation of bone and cartilage base.

It has anti-inflammatory and analgesic properties, reduces release of inflammatory mediators and pain factors into synovial fluid through synoviocytes and synovial macrophages, inhibits secretion of leukotriene B4 and prostaglandin E2.

The ARTRADOL promotes restoration of cartilaginous surfaces of joints, prevents collapse of connective tissue; normalizes production of joint fluid, which leads to improvement of joint mobility and reduction of pain intensity.
With structural similarity to heparin it potentially prevents formation of fibrin clots in the synovial and subchondral microcirculatory channel.

Pharmacokinetics:

Absorption and distribution

Chondroitin sulfate is readily absorbed by injection/m, detectable in significant concentrations in blood after 30 min and in synovial fluid after 15 min. Cmax is reached 1 h after injection, then drug concentration slowly decreases over 2 days. The drug accumulates mainly in the cartilage (Cmax in articular cartilage is reached after 48 hours).

Elimination

Extracted by the kidneys within 24 hours.

Indications

Degenerative-dystrophic diseases of the joints and spine:
– primary arthritis;
– osteoarthritis with predominant involvement of large joints;
– intervertebral osteochondrosis.

Active ingredient

Composition

1 ampoule contains chondroitin sulfate 100 mg.

How to take, the dosage

Artradol is administered intramuscularly, 0.1 g every other day.

Before use the contents of the ampoule is dissolved in 1 ml of water for injection.

In case of good tolerance the dose is increased to 0.2 g starting with the 4th injection.

The course of treatment is 25-35 injections.

The repeated course is in 6 months.

The duration of repeated courses of treatment is determined by the doctor.

Interaction

It is possible to increase the effect of indirect anticoagulants, antiaggregants, fibrinolytic agents, which requires more frequent monitoring of blood clotting when used together.

Contraindications

Hypersensitivity, childhood (effectiveness and safety have not been established).

With caution use in bleeding, susceptibility to bleeding, thrombophlebitis.

Also in pregnancy and lactation.

Side effects

Allergic reactions, hemorrhages at the injection site.

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