Arthrosilen, gel 5% 50 g

It has anti-inflammatory, analgesic and antipyretic effects. By inhibiting COX-1 and -2 it inhibits the synthesis of PG. It has anti-bradykinin activity, stabilizes lysosomal membranes and inhibits the release of enzymes from them that contribute to tissue destruction during chronic inflammation. It reduces release of cytokines, inhibits activity of neutrophils.

Limits morning stiffness and swelling of the joints and increases range of motion.

Ketoprofen lysine salt, unlike ketoprofen, is a rapidly soluble molecule with a neutral pH and is almost non-irritating to the gastrointestinal tract.

When used topically, it has a local anti-inflammatory, anti-exudative and analgesic effect. In the form of a spray or gel it provides local therapeutic effect on the affected joints, tendons, ligaments, muscles. < br>

In joint syndrome, it relieves joint pain at rest and on movement, reduces morning stiffness and joint swelling. The lysine salt of ketoprofen has no catabolic effect on articular cartilage.

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Indications

Active ingredient

Composition

1 g of gel contains ketoprofen lysine salt 50 mg

How to take, the dosage

A single dose of the gel is 3-5 g (volume of a large cherry), the aerosol is 1-2 g (volume of a walnut).

Depending on the size of the damaged area, the drug should be applied 2-3 times a day or as prescribed by the doctor, rubbing gently until completely absorbed.

In ionophoresis, the product is applied to the negative pole.

The duration of treatment without a doctor’s consultation should not exceed 10 days.

Interaction

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) in concurrent use with the drug Arthrozilen increase metabolism of ketoprofen (increase the production of hydroxylated active metabolites).

With the simultaneous use of the preparation Artrozilen the effectiveness of uricosuric drugs decreases, the effect of anticoagulants, antiaggregants, fibrinolytics, ethanol, the side effects of mineralocorticoids, glucocorticoids, estrogens; the effectiveness of antihypertensive drugs and diuretics decreases.

The simultaneous use of the drug Artrosilen with other NSAIDs, GCS, ethanol, corticotropin may lead to ulceration and gastrointestinal bleeding, and increased risk of renal dysfunction.

The simultaneous administration of Artrosilen with oral anticoagulants, heparin, thrombolytics, antiaggregants, cefoperazone, cefamandole and cefotetan increases the risk of bleeding.

The drug Artrosilen when used concomitantly increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (recalculation of the dose is necessary).

The co-administration of Artrozilen with sodium valproate causes platelet aggregation disorders.

Ketoprofen when used concomitantly increases the plasma concentrations of verapamil and nifedipine, lithium, methotrexate.

Antacids and colestiramine decrease the absorption of ketoprofen when concomitant use with the drug Arthrozilen.

Special Instructions

The product should be applied only to intact skin. Avoid contact with eyes and mucous membranes.

In order to avoid hypersensitivity and photosensitivity, it is recommended to avoid exposing the skin to sunlight during the course of treatment.

Contraindications

Side effects

Gastrointestinal organs: abdominal pain, diarrhea, stomatitis, esophagitis, gastritis, duodenitis, erosive gastrointestinal ulcers, hematomeisis, melena.

Hepatic system disorders: increased bilirubin level, increased liver enzyme activity, hepatitis, liver failure, increased liver size.

Nervous system disorders: dizziness, hyperkinesia, tremor, vertigo, mood swings, anxiety, hallucinations, irritability, general malaise.

Sensory organs: conjunctivitis, visual impairment.

Skin disorders: urticaria, angioedema, erythematous exanthema, pruritus, maculopapular exanthema, increased sweating, erythema multiforme (including Stevens-Johnson syndrome).

Urogenital system disorders: painful urination, cystitis, edema, hematuria, menstrual disorders.

Hematopoietic disorders: leukocytopenia, leukocytosis, lymphangitis, decreased PV, thrombocytopenia, thrombocytopenic purpura, increased spleen size, vasculitis.

Respiratory system: bronchospasm, dyspnea, sensation of laryngeal spasm, laryngospasm, laryngeal edema, rhinitis.

Cardiovascular system: hypertension, hypotension, tachycardia, chest pain, syncope, peripheral edema, paleness.

Allergic reactions: anaphylactoid reactions, oral mucous membrane edema, pharyngeal edema, periorbital edema.

Overdose

There are currently no reported cases of overdose with the drug Arthrosilen.

Pregnancy use

It should not be used in the third trimester of pregnancy.

There is no experience of using Arthrosilen during lactation.

The use in I and II trimesters is possible only after consultation with the doctor.

It is contraindicated for children under 6 years of age.

Similarities