Arpeflu, 50 mg 30 pcs.

Antiviral drug, has immunomodulatory and anti-flu effects, specifically suppresses influenza viruses A and B.

It has interferon-inducing properties, stimulates humoral and cellular immune reactions, phagocytic function of macrophages, increases resistance of the body to viral infections. It prevents the development of post-flu complications, reduces the frequency of exacerbations of chronic diseases, normalizes immunological parameters.

The antiviral action is due to the suppression of the fusion of the lipid shell of the virus with the cell membranes when the virus comes into contact with the cell. Therapeutic effectiveness in influenza is shown in reduction of intoxication and severity of catarrhal symptoms, shortening of periods of fever and overall duration of the disease.

The drug is low-toxic (LD 50>4 g/kg). It does not have any negative effect on the human body when administered orally in recommended doses.

Pharmacokinetics

Absorption is fast. Rapidly distributed to organs and tissues. TCmax at a dose of 50 mg – 1.2 h, 100 mg – 1.5 h. Metabolized in the liver. T1/2 is 17-21 hours. About 40% is eliminated unchanged, mainly in bile (38.9%) and in small amount in kidney (0.12%). During the first day 90% of the administered dose is excreted.

Indications

Treatment and prevention of flu and other acute respiratory infections (including those complicated by bronchitis and pneumonia); chronic bronchitis, pneumonia, recurrent herpes infection (in the complex treatment); for the prevention of infectious complications and normalization of immune status in the postoperative period.

Active ingredient

Composition

Active Substance:

Ethyl ester of 6-bromo-5-hydroxy-1-methyl-4-dimethylaminomethyl-2-phenylthiomethylindol-3-carboxylic acid hydrochloride monohydrate – 50 mg.

How to take, the dosage

Ingestion, before meals. Single dose: For children from 3 to 6 years old – 50 mg, from 6 to 12 years old – 100 mg, over 12 years old and adults – 200 mg (2 tablets of 100 mg or 4 tablets of 50 mg).

For non-specific prophylaxis

In direct contact with patients with influenza and other acute respiratory infections: for children from 3 to 6 years – 50 mg, for 6 to 12 years – 100 mg, over 12 years and adults – 200 mg once a day for 10-14 days.

During epidemics of influenza and other acute respiratory infections, to prevent exacerbations of chronic bronchitis, relapse of herpetic infection: to children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, older than 12 years and adults – 200 mg 2 times a week for 3 weeks.

Prevention of postoperative complications: in children 3 to 6 years old – 50 mg, 6 to 12 years old – 100 mg, over 12 years old and adults – 200 mg 2 days before surgery, then on the 2nd and 5th days after surgery.

To treat

Influenza, other acute respiratory infections without complications: children 3 to 6 years – 50 mg, 6 to 12 years – 100 mg, over 12 years and adults – 200 mg 4 times a day (every 6 hours) for 5 days.

Influenza, other acute respiratory infections with development of complications (bronchitis, pneumonia and others): children 3 to 6 years old – 50 mg, 6 to 12 years old – 100 mg, over 12 years old and adults – 200 mg 4 times a day (every 6 hours) for 5 days, then a single dose once a week for 4 weeks.

Interaction

No adverse effects have been noted when prescribed with other medications.

Special Instructions

It does not exhibit central neurotropic activity and can be used in medical practice for prophylactic purposes in practically healthy individuals in various professions, including those requiring increased attention and coordination of movements (drivers, operators and so on).

Contraindications

Side effects

Allergic reactions.

Similarities