Arpeflu, 50 mg 10 pcs

Antiviral drug, has immunomodulatory and anti-flu effects, specifically suppresses influenza viruses A and B.

It has interferon-inducing properties, stimulates humoral and cellular immune reactions, phagocytic function of macrophages, increases resistance of the body to viral infections. It prevents the development of post-flu complications, reduces the frequency of exacerbations of chronic diseases, normalizes immunological parameters.

The antiviral action is due to the suppression of the fusion of the lipid shell of the virus with the cell membranes when the virus comes into contact with the cell. Therapeutic effectiveness against influenza is realized in reduction of intoxication and severity of catarrhal symptoms, shortening of the period of fever and the total duration of the disease. It belongs to low-toxic medicines (LD 50>4 g/kg). It does not have any negative effect on human body when administered orally in recommended doses.

Pharmacokinetics

Absorption is fast. Rapidly distributed to organs and tissues. TCmax at a dose of 50 mg – 1.2 h, 100 mg – 1.5 h. Metabolized in the liver. T1/2 is 17-21 hours. About 40% is eliminated unchanged, mainly in bile (38.9%) and in small amount in kidney (0.12%). During the first day 90% of the administered dose is eliminated.

Indications

Arpeflu is used for treatment and prevention of acute respiratory infections of viral etiology, influenza B and A, as well as complications that developed against these diseases.

Arpeflu may be administered as part of complex therapy of chronic bronchitis, recurrent herpetic infection of various localizations, and pneumonia.

The tablets Arpeflu are used for prevention of postoperative complications and for normalization of the immune status of patients.

Arpeflu is indicated in the treatment of acute intestinal infections caused by rotavirus in patients over 3 years old.

Active ingredient

Composition

Active ingredient:

ethyl ester of 6-

bromo-5-

hydroxy-1-

methyl-4-

dimethylaminomethyl-

2-phenylthiomethylindole

-3-carboxylic acid

hydrochloride monohydrate 50 mg.

How to take, the dosage

Ingestion, before meals. Single dose: for children from 3 to 6 years old – 50 mg, from 6 to 12 years old – 100 mg, over 12 years old and adults – 200 mg (2 tablets of 100 mg or 4 tablets of 50 mg).

For non-specific prophylaxis

In direct contact with patients with influenza and other SARS: children 3 to 6 years – 50 mg, 6 to 12 years – 100 mg, older than 12 years and adults – 200 mg once a day for 10-14 days.

During epidemics of influenza and other acute respiratory infections, to prevent exacerbations of chronic bronchitis, relapse of herpetic infection: to children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, older than 12 years and adults – 200 mg 2 times a week for 3 weeks.

Prevention of postoperative complications: in children 3 to 6 years old – 50 mg, 6 to 12 years old – 100 mg, over 12 years old and adults – 200 mg 2 days before surgery, then on the 2nd and 5th days after surgery.

Treatment

Flu, other acute respiratory infections without complications: children 3 to 6 years – 50 mg, 6 to 12 years – 100 mg, over 12 years and adults – 200 mg 4 times a day (every 6 hours) for 5 days.

Influenza, other acute respiratory infections with development of complications (bronchitis, pneumonia and others): children 3 to 6 years old – 50 mg, 6 to 12 years old – 100 mg, over 12 years old and adults – 200 mg 4 times a day (every 6 hours) for 5 days, then a single dose once a week for 4 weeks.

Special Instructions

It does not exhibit central neurotropic activity and can be used in medical practice for prophylactic purposes in practically healthy individuals in various professions, including those requiring increased attention and coordination of movements (drivers, operators and so on).

Contraindications

Arpeflu is not used in the treatment of patients with personal intolerance to arbidol hydrochloride or additional components of the tablets.

Arpeflu is not indicated in patients with lactose intolerance (including lactase deficiency, glucose-galactose malabsorption and galactosemia).

In pediatric practice Arpeflu is prescribed only for the treatment of children over 3 years of age.

Side effects

Allergic reactions.

Similarities