Argosulfan, 2% cream 40 g

Preparation with antibacterial action for external use. It promotes healing of wounds (burns, trophic, purulent), provides effective protection from infection, reduces treatment time and wound preparation time for skin grafting, in many cases leads to improvement of condition excluding the need for transplantation.

The silver sulfonamide contained in the cream is an antimicrobial and bacteriostatic agent that has a broad spectrum of antibacterial action against Gram-positive and Gram-negative bacteria.

The mechanism of antimicrobial action of sulfathiazole – inhibition of microbial growth and reproduction – is associated with competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase, which leads to disruption of dihydrofolic acid synthesis and eventually its active metabolite – tetrahydrofolic acid, required for synthesis of purines and pyrimidines of microbial cells.

Silver ions present in the drug enhance antibacterial action of sulfonamide – they inhibit bacterial growth and division by binding to deoxyribonucleic acid of the microbial cell. In addition, silver ions weaken the sensitizing properties of sulfonamidanilamide. Due to minimal resorption, the drug has no toxic effect.

Indications

Active ingredient

Composition

1 g of the cream contains:

The active ingredient:

sulfathiazole silver salt 20 mg.

Base: up to 1 g.

Base components:

liquid paraffin;

cetostearyl alcohol;

Vaseline;

sodium lauryl sulfate;

Glycerin;

propyl hydroxybenzoate;

methyl hydroxybenzoate;

potassium hydrophosphate;

sodium dihydrophosphate;

water for injection.

How to take, the dosage

Interaction

The use with other topical medications is not recommended.

Folic acid and its structural analogues (e.g. procaine) can weaken the antimicrobial activity of sulfathiazole.

Special Instructions

Contraindications

Side effects

Skin allergic reactions.

Sometimes there may be irritation, manifested by burning at the site of application of the cream.

Long-term use may lead to blood changes characteristic of systemic sulfonamides (e.g., leukopenia), desquamative dermatitis.

Overdose