Anti-Flu Kids, 5 pcs.

Pharmacotherapeutic group

The remedy for acute respiratory infections and “cold” symptoms (analgesic non-narcotic + H1-histamine receptor blocker + vitamin).

ATC code: N02BE51

Pharmacological properties

The combined medicine with vitamin C and raspberry flavor. Paracetamol (acetami-nophen) has analgesic and antipyretic effect.

Ascorbic acid (vitamin C) increases resistance to infections and improves the tolerance of paracetamol.

Chlorpheniramine maleate has anti-allergic effect, eliminates runny nose, lacrimation, itching in the eyes and nose. Quickly relieves fever, headache and 2 muscle pain, sore throat, runny nose.

Indications

Symptomatic treatment of SARS, including flu and “colds” in children from 2 to 12 years accompanied by high fever, chills, body aches, headache and muscle pain, sore throat, runny nose, stuffy nose, lacrimation, sneezing.

Composition

Powder for the preparation of a solution for oral administration.

Per sachet:

Active ingredients:

Paracetamol (acetaminophen) 160 mg,

ascorbic acid 50 mg,

Chlorpheniramine maleate 1 mg.

Auxiliary substances:

citric acid 50 mg,

dye Red Charming 0.05 mg,

p> raspberry flavoring 100 mg,

silicon dioxide (siloxide) 4 mg,

silicon dioxide 20 mg,

sodium citrate dihydrate 2 mg,

corn starch 1 mg,

powdered sugar 2794.95 mg,

/p>

sucrose 8800 mg,

titanium dioxide 1 mg,

calcium phosphate 1 mg.

How to take, the dosage

Ingestion.

A single dose for children 2-5 years of age is the contents of 1 sachet, for children 6-12 years – the contents of 2 sachets.

Take orally, regardless of meals, dissolving the contents of the bag in 150 ml of warm water.

If necessary, repeat every 4-6 hours, but not more than 3 doses during the day.

If the temperature does not decrease, does not stop the pain, chills, runny nose – be sure to consult a doctor.

The total duration of treatment should not exceed 5 days.

Interaction

It is not recommended to take simultaneously with sleeping pills, sedatives and drugs containing alcohol.

Enhances blood concentrations of benzylpenicillin and tetracyclines. Improves intestinal absorption of iron preparations (converts trivalent iron to divalent iron); may increase iron excretion when used simultaneously with deferoxamine. Increases the risk of crystalluria during treatment with salicylates and short-acting sulfonamides, slows renal excretion of acids, increases excretion of drugs with an alkaline reaction (including alkaloids), reduces the blood concentration of oral contraceptives. Increases the total clearance of ethanol. Simultaneous use reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, channel reabsorption of amphetamine and tricyclic antidepressants. Reduces the effectiveness of uricosuric drugs.

Can both increase and decrease the effect of anticoagulant drugs. Paracetamol (or its metabolites) interacts with enzymes involved in vitamin K – dependent synthesis of clotting factor. Interactions between paracetamol and warfarin or coumarin derivatives may lead to an increase in the international normalized ratio (INR) and an increased risk of bleeding. Patients taking oral anticoagulants should not take paracetamol long-term without medical supervision.

Ethanol increases the sedative effect of chlorphenamine. Antidepressants, antiparkinsonian and phenothiazine antipsychotic drugs increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids increase the risk of glaucoma.

The inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase production of hydroxylated active metabolites of paracetamol, which causes the possibility of severe hepatotoxic reactions even in small overdose. Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects of paracetamol. Diflunisal increases the plasma concentration of paracetamol by 50% and increases hepatotoxicity. Ethanol reduces the concentration of ascorbic acid in the body and also contributes to the development of acute pancreatitis. The use of barbiturates reduces the effectiveness of paracetamol, increases excretion of ascorbic acid with urine. Increases the effect of sleeping pills.

Concomitant use with chloramphenicol may increase its half-life from the blood plasma and increase its toxic effect.

Drugs that lead to delayed gastric emptying, such as propantelin, may lead to delayed absorption of paracetamol and thereby delay its onset of action.

Drugs that lead to accelerated gastric emptying, such as metoclopramide, may lead to more rapid absorption of paracetamol and thus accelerate its onset of action.

The antagonists tropisetron and granisetron, 5-hydroxytryptamine type 3 can completely inhibit the analgesic effects of paracetamol through pharmacodynamic interaction.

Paracetamol should not be taken together with zidovudine without a physician’s recommendation because of an increased tendency to lower white blood cell count (neutropenia).

Continuous combination therapy with more than one analgesic should be avoided; because of possible summation of side effects.

Special Instructions

Considering the ability of the drug to cause drowsiness, children should be withdrawn from activities requiring increased concentration for 4 hours after taking the drug.

Contains natural sugar. Each sachet contains 1 BE.

A very rare case of serious skin reactions has been reported. If skin redness, rashes, blisters, or peeling occurs, you should stop using paracetamol and see a doctor immediately.

Paracetamol and ascorbic acid may distort laboratory tests (quantitative determination of plasma glucose and uric acid, bilirubin, activity of “liver” transaminases, LDH).

In case of hyperthermia lasting more than 3 days and pain syndrome of more than 5 days, it is necessary to consult a physician.

Contraindications

Hypersensitivity to individual components of the drug, marked liver and renal dysfunction, closed-angle glaucoma, prostate hypertrophy, sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, children under 2 years of age.

With caution use in: arterial hypertension, severe cardiovascular disease, diabetes, bronchial asthma, chronic obstructive pulmonary disease, thyrotoxicosis, pheochromocytoma, urinary difficulties with prostate adenoma, In addition to the above mentioned, the use of the medicinal product should be accompanied by the use of the antibacterial agent for the treatment of other blood diseases, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson, and Rothera syndromes), advanced malignant diseases, viral hepatitis, hyperoxalaturia, glucose-6-phosphate dehydrogenase deficiency.

Side effects

Allergic reactions: cutaneous rash, pruritus, urticaria, toxic epidermal necrolysis (Lyell’s syndrome), erythema polymorphicum bullosa (Stevens-Johnson syndrome), acute generalized exanthematous pustulosis, angioedema (Quincke’s edema), anaphylactic shock.

From the central nervous system: dizziness, sleep disturbance (drowsiness), headache, excitability, decreased speed of psychomotor reactions, feeling of fatigue.

With the hematopoietic system: anemia, thrombocytopenia, thrombocytopenic purpura, leukopenia, pancytopenia, agranulocytosis, hemolytic anemia, methemoglobinemia.

From the digestive system: nausea, vomiting, stomach discomfort, abdominal pain, diarrhea.

Hepatic and biliary tract disorders: liver damage (increased activity of “liver” enzymes), hepatitis, and dose-dependent liver failure, liver necrosis. Prolonged unjustified use may lead to liver fibrosis, cirrhosis.

Urinary system disorders: urinary retention, with prolonged high dose nephrotoxic effects.

Respiratory system disorders: bronchospasm or exacerbation of bronchial asthma, including in patients sensitive to acetylsalicylic acid or other NSAIDs.

Others: mydriasis, paresis of accommodation, increased intraocular pressure.

Overdose

In case of overdose it is necessary to seek medical help immediately.

Paracetamol

Symptoms: diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and/or abdominal pain, increased sweating. The clinical picture of acute paracetamol overdose develops within 6-14 hours after taking paracetamol. Symptoms of chronic overdose occur 2-4 days after increasing the dose of the drug. In severe poisoning severe hepatic failure may develop up to hepatic encephalopathy, coma and death. Hypokalemia and metabolic acidosis (including lactoacidosis) may also develop in acute and/or chronic overdose. Common clinical manifestations after 3-5 days are jaundice, fever, liver breath, hemorrhagic diathesis, hypoglycemia, liver failure. Acute renal failure with acute tubular necrosis, which is diagnosed by severe lumbar pain, hematuria, and proteinuria, may develop without severe liver function impairment.

Treatment: gastric lavage, activated charcoal in the first 6 hours, administration of SH-group donators and precursors of glutathione synthesis – methionine in 8-9 hours after overdose and N-acetylcysteine in 12 hours.

Chlorpheniramine

Symptoms:dizziness, agitation, sleep disturbances, depression, seizures and coma.

Treatment: symptomatic.

Ascorbic acid

High doses of ascorbic acid (more than 3000 mg) may cause temporary osmotic diarrhea and gastrointestinal disturbances such as nausea, stomach discomfort.

Treatment: symptomatic, forced diuresis.

Pregnancy use

It is not recommended for use in pregnancy and during breastfeeding.