Amoxiclav Quicktab, 500 mg+125 mg 14 pcs

Amoxiclav Quicktab is a broad spectrum antibiotic; contains semi-synthetic penicillin amoxicillin and b-lactamase inhibitor clavulanic acid. Clavulanic acid inhibits most clinically relevant b-lactamases (types 2, 3, 4 and 5 – according to Richmond Sykes classification) produced by Staphylococcus spp., Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides spp. Inactive against type 1 b-lactamases produced by Enterobacter spp., Morganella morganii, Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.

This combination provides high bactericidal activity of Amoxiclav (including against strains of microorganisms resistant to amoxicillin). Clavulanic acid, having higher affinity to b-lactamase than amoxicillin, forms a stable deactivated complex with the enzyme, preventing enzymatic degradation of amoxicillin under the action of b-lactamases.

Thus, Amoxiclav acts bactericidally on a wide range of Gram-positive and Gram-negative bacteria (including strains that have acquired resistance to beta-lactam antibiotics due to production of b-lactamases).

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
– infections of the upper respiratory tract and ENT organs (including acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsillitis, pharyngitis);
– infections of the lower respiratory tract (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);
– urinary tract infections;
– gynecological infections;
– infections of the skin and soft tissues;
– infections of bones and joints;
– biliary tract infections (cholecystitis, cholangitis);
– odontogenic infections.

Pharmacological effect

Amoxiclav Quiktab is a broad-spectrum antibiotic; contains semisynthetic penicillin amoxicillin and b-lactamase inhibitor clavulanic acid. Clavulanic acid inhibits most clinically significant b-lactamases (types 2, 3, 4 and 5 – according to the Richmond Sykes classification) produced by Staphylococcus spp., Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides spp. Inactive against type 1 b-lactamases produced by Enterobacter spp., Morganella morganii, Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.

This combination provides high bactericidal activity of Amoxiclav (including against strains of microorganisms resistant to amoxicillin). Clavulanic acid, having a higher affinity for b-lactamase than amoxicillin, forms a stable deactivated complex with the enzyme, preventing the enzymatic degradation of amoxicillin under the action of b-lactamases.

Thus, Amoxiclav has a bactericidal effect on a wide range of gram-positive and gram-negative bacteria (including strains that have become resistant to beta-lactam antibiotics due to the production of b-lactamases).

Special instructions

During a course of treatment, the function of hematopoiesis, liver and kidneys should be monitored.

In patients with severely impaired renal function, adequate adjustment of the dosage regimen or increased intervals between dosing is required.

In order to reduce the risk of developing adverse reactions from the gastrointestinal tract, the drug should be taken with meals.

When using Amoxiclav, a false-positive reaction is possible when determining the level of glucose in urine using Benedict’s reagent or Felling’s solution (it is recommended to use enzymatic reactions with glucose oxidase).

Concomitant use with disulfiram should be avoided.

Active ingredient

Amoxicillin, Clavulanic acid

Composition

1 tablet (625 mg) contains amoxicillin (as trihydrate) 500 mg and clavulanic acid (as potassium salt) 125 mg

Pregnancy

Amoxicillin and clavulanic acid pass into breast milk in small quantities.

Amoxiclav can be used during pregnancy in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

Contraindications

– cholestatic jaundice or impaired liver function caused by a history of taking amoxicillin/clavulanic acid;
– hypersensitivity to amoxicillin, clavulanic acid or penicillins.

The drug should be prescribed with caution in case of allergic reactions to cephalosporins and a history of pseudomembranous colitis, liver failure, and severe renal dysfunction.

Due to the fact that an erythematous rash was observed in a large number of patients with infectious mononucleosis and lymphocytic leukemia treated with ampicillin, the use of ampicillin antibiotics in such patients is not recommended.

Side Effects

From the digestive system: possible loss of appetite, nausea, vomiting, diarrhea; rarely – transient increase in the activity of liver enzymes (ALT, AST), liver dysfunction; in isolated cases – cholestatic jaundice, hepatitis, pseudomembranous colitis.

Allergic reactions: erythematous rash, itching, urticaria; rarely – exudative erythema multiforme, angioedema, anaphylactic shock; in isolated cases – exfoliative dermatitis, Stevens-Johnson syndrome.

Other: rarely – development of superinfection, candidiasis.

Interaction

With the simultaneous use of Amoxiclav and indirect anticoagulants, an increase in prothrombin time is observed. Therefore, this combination is prescribed with caution.

When Amoxiclav is used simultaneously with allopurinol, the risk of developing side effects such as exanthema increases.
With simultaneous use, Amoxiclav increases the toxicity of methotrexate.

The combination of Amoxicillin with rifampicin is antagonistic (mutual weakening of the antibacterial effect is noted).

Amoxiclav should not be used simultaneously with bacteriostatic antibiotics (macrolides, tetracyclines), sulfonamides due to a possible decrease in the effectiveness of Amoxiclav.

When used simultaneously, Amoxiclav reduces the effectiveness of oral contraceptives.

Overdose

Symptoms: abdominal pain, diarrhea, vomiting; Anxiety, insomnia, dizziness are also possible; in some cases – convulsions.

Treatment: in case of recent use of the drug (less than 4 hours), it is necessary to perform gastric lavage and prescribe activated charcoal to reduce the absorption of the drug; If necessary, carry out symptomatic therapy.

Hemodialysis is effective.

Storage conditions

In a place protected from moisture, at a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

Lek d.d., Slovenia