Amoxiclav Quicktab, 500 mg+125 mg 14 pcs

Amoxiclav Quicktab is a broad spectrum antibiotic; contains semi-synthetic penicillin amoxicillin and b-lactamase inhibitor clavulanic acid. Clavulanic acid inhibits most clinically relevant b-lactamases (types 2, 3, 4 and 5 – according to Richmond Sykes classification) produced by Staphylococcus spp., Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides spp. Inactive against type 1 b-lactamases produced by Enterobacter spp., Morganella morganii, Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.

This combination provides high bactericidal activity of Amoxiclav (including against strains of microorganisms resistant to amoxicillin). Clavulanic acid, having higher affinity to b-lactamase than amoxicillin, forms a stable deactivated complex with the enzyme, preventing enzymatic degradation of amoxicillin under the action of b-lactamases.

Thus, Amoxiclav acts bactericidally on a wide range of Gram-positive and Gram-negative bacteria (including strains that have acquired resistance to beta-lactam antibiotics due to production of b-lactamases).

Indications

Treatment of infections and inflammatory diseases caused by microorganisms sensitive to the drug:
– Upper respiratory tract and ENT-organs infections (including acute and chronic sinusitis, acute and chronic otitis, tonsillitis, pharyngitis);
– Infections of the lower respiratory tract (including acute and chronic sinusitis, tonsillitis and pharyngitis). Acute and chronic sinusitis, acute and chronic otitis, tonsillitis, pharyngitis);
– Lower respiratory tract infections (including
– lower respiratory tract infections (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);
– urinary tract infections;
– gynecological infections;

Active ingredient

Composition

1 tablet (625 mg) contains amoxicillin (as trihydrate) 500 mg and clavulanic acid (as potassium salt) 125 mg

How to take, the dosage

Tablets Amoxiclav Quicktab are taken orally by first dissolving in half a glass of water (at least 30 ml) and stirring thoroughly. It is possible to hold the tablets in the mouth until they are completely dissolved, and then swallow them. In order to reduce the risk of gastrointestinal side effects, the drug should be taken at the beginning of meals.

Adults and children over 12 years of age (body weight >40 kg) in case of mild or moderate infection take 1 tablet (625 mg) every 12 hours, in case of severe infection and respiratory tract infections – 1 tablet (625 mg) every 8 hours or 1 tablet (1000 mg) every 12 hours.

The duration of treatment is up to 14 days.

In case of initiating treatment with parenteral administration of the drug it is possible to continue therapy by oral administration of Amoxiclav Quicktab tablets.

In accordance with the severity of renal functional impairment the dose of the drug should be reduced and / or the interval of administration should be increased. In moderate renal failure (CKD 10-30 ml/min) 1 tablet (625 mg) every 12 hours is prescribed. In severe renal failure (CKD

5 ml/min)

Interaction

When concomitant use of Amoxiclav and indirect anticoagulants increased prothrombin time is observed. Therefore, this combination is prescribed with caution.

In concomitant use of Amoxiclav with allopurinol the risk of side effects such as exanthema increases.
In concomitant use Amoxiclav increases toxicity of methotrexate.

The combination of Amoxicillin with rifampicin is antagonistic (mutual weakening of antibacterial action is noted).

Amoxiclav should not be used simultaneously with bacteriostatic antibiotics (macrolides, tetracyclines), sulfonamides due to a possible reduction of Amoxiclav effectiveness.

When used concomitantly Amoxiclav decreases the effectiveness of oral contraceptives.

Special Instructions

Hematopoietic, hepatic and renal function should be monitored during treatment.

In patients with severe renal dysfunction, adequate dosing adjustment or increased dosing intervals are required.

In order to reduce the risk of gastrointestinal adverse reactions, the drug should be taken with meals.

When using Amoxiclav a false positive reaction is possible when determining the glucose level in the urine using Benedict’s reagent or Felling’s solution (enzymatic reactions with glucose oxidase are recommended).

The concomitant administration with disulfiram should be avoided.

Contraindications

– cholestatic jaundice or liver dysfunction caused by taking amoxicillin/clavulanic acid in the history;
– hypersensitivity to amoxicillin, clavulanic acid or penicillins.

The drug should be administered with caution in allergic reactions to cephalosporins and pseudomembranous colitis in the history, hepatic insufficiency, severe renal impairment.

With regard to the fact that a large number of patients with infectious mononucleosis and lymph leukemia who received ampicillin had an erythematous rash, use of ampicillin antibiotics in these patients is not recommended.

Side effects

Digestive system: loss of appetite, nausea, vomiting, diarrhea; rarely – transient increase of liver enzymes activity (ALT, AST), liver dysfunction; in single cases – cholestatic jaundice, hepatitis, pseudomembranous colitis.

Allergic reactions: erythematous rash, pruritus, urticaria; rarely – erythema multiforme, angioedema, anaphylactic shock; in single cases – exfoliative dermatitis, Stevens-Johnson syndrome.

Others: rare – development of superinfection, candidiasis.

Overdose

Symptoms: abdominal pain, diarrhea, vomiting; anxiety, insomnia, dizziness, seizures are also possible.

Treatment: if the drug was taken recently (less than 4 hours) gastric lavage should be performed and activated carbon should be prescribed to reduce absorption; if necessary symptomatic therapy should be used.

Hemodialysis is effective.

Pregnancy use

Amoxicillin and clavulanic acid penetrate into breast milk in small amounts.

Amoxiclav can be used in pregnancy in cases where the expected benefit to the mother exceeds the potential risk to the fetus.

Similarities