Amoxicillin Ecobol, tablets 500 mg 20 pcs

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Indications

Bacterial infections caused by sensitive microflora:

– Respiratory and ENT organ infections (sinusitis, pharyngitis, tonsillitis, acute otitis media; bronchitis, pneumonia);

– infections of the urogenital system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis);

– gastrointestinal infections (enterocolitis, typhoid, cholangitis, cholecystitis);

– skin and soft tissue infections (rye, impetigo, secondary infected dermatoses);

– leptospirosis;

– listeriosis;

– Lyme disease (borreliosis);

– dysentery;

– salmonellosis, salmonell carrier;

– endocarditis (prevention).

Active ingredient

Composition

1 tablet amoxicillin (in the form of trihydrate) 500 mg

Supplementary substances:

Lactulose – 600 mg,

povidone low molecular weight – 10 mg,

How to take, the dosage

The drug is taken orally, before or after meals.

Adults and children over 10 years of age (with body weight over 40 kg) are prescribed 0.5 g 3 times a day; in severe course of infection – 0.75-1.0 g 3 times a day.

In children aged 5-10 years old 0.25 g 3 times per day; in children aged 3-5 years old 0.125 g 3 times per day; in severe course of infection 60 mg/kg/day in 3 times (maximum daily dose).

The course of treatment is 5-12 days.

In acute uncomplicated gonorrhea 3 g is prescribed once; when treating women, a second administration of the indicated dose is recommended.

In acute gastrointestinal infections (paratyphoid, typhoid) and biliary tract, in gynecological infections adults are prescribed 1.5-2 g 3 times/day or 1-1.5 g 4 times/day.

In leptospirosis adults are prescribed 0.5-0.75 g 4 times a day for 6-12 days.

In case of Salmonella carriage adults are prescribed 1.5-2 g 3 times a day for 2-4 weeks.

In prophylaxis of endocarditis during minor surgical interventions in adults it is prescribed 3-4 g 1 hour before the procedure. If necessary a second dose is prescribed after 8-9 hours. In children the dose is reduced twice.

In patients with impaired renal function at IQ of 15-40 ml/min, the interval between doses is increased to 12 hours; at IQ below 10 ml/min, the dose is reduced by 15-50%; in anuria the maximum dose is 2 g/day.

Interaction

Increases the effectiveness of indirect anticoagulants (by suppressing intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, drugs, in the metabolism of which para-aminobenzoic acid is formed, ethinylestradiol – risk of bleeding “breakthrough”.

Allopurinol increases the risk of developing a skin rash.

Decreases clearance and increases toxicity of methotrexate.

It increases the absorption of digoxin.

Special Instructions

During the course of treatment it is necessary to monitor the hematopoietic, hepatic and renal function.

The development of superinfection due to the growth of microflora resistant to Amoxicillin is possible, which requires appropriate changes in antibiotic therapy.

When treating patients with bacteremia the development of endotoxic shock reaction (Jarisch-Herxheimer reaction) is possible.

In patients with hypersensitivity to penicillins cross-allergic reactions with cephalosporin antibiotics are possible.

In treatment of mild diarrhea during the course of treatment, anti-diarrheal drugs that reduce intestinal peristalsis should be avoided. For severe diarrhea, consultation with a specialist is necessary.

The treatment must be continued for 48-72 hours after the clinical signs of the disease have disappeared.

If estrogen-containing oral contraceptives and amoxicillin are used concomitantly, other or additional contraceptive methods should be used if possible.

Contraindications

– hypersensitivity (including to other penicillins, cephalosporins, carbapenems);

– children under 3 years of age (for this dosage form).

With caution the drug should be prescribed in case of allergic diseases (including history), gastrointestinal diseases in history (especially colitis associated with antibiotic use), renal failure, severe liver function disorders, pregnancy, during lactation, infectious mononucleosis, lympholeukosis.

Side effects

Allergic reactions:It is possible urticaria, skin hyperemia, erythema, angioneurotic edema, rhinitis, conjunctivitis; rarely – fever, joint pain, eosinophilia, exfoliative dermatitis, erythema multiforme exudative, Stevens-Johnson syndrome, reactions similar to serum disease; in single cases – anaphylactic shock.

In the digestive system:dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, impaired liver function, moderate increase in liver transaminases activity, pseudomembranous enterocolitis.

Nervous system disorders:excitement, anxiety, insomnia, ataxia, confusion, behavioral changes, depression, peripheral neuropathy, headache, dizziness, seizure reactions.

Laboratory findings:Leukopenia, neutropenia, thrombocytopenic purpura, anemia.

Others:painful breathing, tachycardia, interstitial nephritis, vaginal candidiasis, superinfection (especially in patients with chronic disease or reduced body resistance).

Overdose

Symptoms: nausea, vomiting, diarrhea, impaired water-electrolyte balance (as a consequence of vomiting and diarrhea).

Treatment: gastric lavage, administration of activated charcoal, saline laxatives, correction of water-electrolyte balance; hemodialysis.

Pregnancy use

The use of the drug during pregnancy is possible only when the estimated benefit to the mother exceeds the potential risk to the fetus.

Breastfeeding should be stopped if the drug has to be administered during lactation.

Similarities