Amlovas, tablets 5 mg 30 pcs

Amlovas is antispasmodic, antihypertensive, vasodilator, antianginal.

Blocks entry of calcium ions through cell membranes into the smooth muscle cells of the myocardium and vessels. It has a direct relaxing effect on vascular smooth muscle, dilates peripheral arterioles, resulting in decreased myocardial pressure, reduces the load on the heart and myocardial oxygen demand, dilates coronary arteries, increasing the flow of oxygen to the myocardium.

Pharmacokinetics

After oral administration, it is quickly and almost completely (90%) absorbed from the gastrointestinal tract. Bioavailability is 60-65%, C< sub> max in plasma is reached after 6-12 h, equilibrium concentration – after 7-8 days.

The volume of distribution is about 20 l/kg, binding to plasma proteins is more than 95%, penetrates through the BBB and into breast milk. Metabolized mainly in the liver with the formation of inactive metabolites, T< sub>1/2 – 35-45 hours. It is excreted by the kidneys (10% – unchanged and 60% – as metabolites) and also with the bile and through the intestine.

Indications

Arterial hypertension (monotherapy and in combination with thiazide diuretics, ACE inhibitors or alpha- and beta-adrenoblockers), angina pectoris (stable and unstable, incl.including Prinzmetal or variant), dilated (non-ischemic) cardiomyopathy with severe chronic heart failure.

Active ingredient

Composition

Active ingredient:

amlodipine 5 mg.

How to take, the dosage

Overly, the initial dose is 5 mg/day; if necessary, the daily dose may be increased to 10 mg. The maximum daily dose is 10 mg.

Special Instructions

The drug should be refrained from use in pediatric practice, since the safety and efficacy of its use in children has not been determined.

Patients with liver dysfunction, aortic orifice stenosis, chronic heart failure should be treated with caution.

Contraindications

Hypersensitivity, arterial hypotension.

Side effects

Nervous system and sensory organs: dizziness, headache, drowsiness, fatigue; rarely – change of mood, asthenia, seizures, myalgia, visual disturbances, paresthesia.

Cardiovascular system and blood (hematopoiesis, hemostasis): palpitations, hot flashes.

Gastrointestinal system disorders: nausea, abdominal pain, dyspeptic complaints; rarely – gum hyperplasia, increased liver transaminases, jaundice.

Urogenital system disorders: increased frequency of urination, edema, impotence.

Skin disorders: allergic reactions (skin rash, itching), rarely erythema multiforme.

Others: rarely – shortness of breath, gynecomastia.

Overdose

Symptoms: pronounced arterial hypotension.

Treatment: maintenance of cardiovascular function, monitoring of heart and lung function, elevation of extremities, control of blood circulation and diuresis, use of vasoconstrictors, administration of calcium gluconate (IV).

Similarities