Ambrobene Stoptussin, drops 25 ml

Pharmacodynamics
Combined drug with anti-cough and expectorant effect.
Butamirat has a peripheral local anesthetic effect on sensitive nerve endings of the bronchial mucosa, which provides anti-cough effect.
Guaifenesin increases secretion of bronchial glands and decreases mucus viscosity. Increased secretion is caused both by direct action on bronchial glands – stimulation of secretion from bronchial glands and removal of acidic glycoproteins from acinar cells, and by reflex way, when there is irritation of afferent parasympathetic fibers of gastric mucosa and inhibition of respiratory center. Increase of tone of the vagus nerve (n. vagus) stimulates production of bronchial secretion. Mucus produced by bronchial glands increases activity of ciliated epithelium, resulting in easier evacuation of mucus from the bronchi and coughing it up.
Pharmacokinetics
When administered orally butamirate citrate is quickly and completely absorbed. Binding with plasma proteins is 94%. It is metabolized to form
2 metabolites, also having antitussive effect. Metabolites are excreted mainly (90%) by kidneys and only small part is excreted through intestine.
The half-life (T½) is 6 hours.
Guaifenesin when taken orally is quickly absorbed from the gastrointestinal tract. Binding to plasma proteins is insignificant. Guaifenesin is rapidly metabolized, with the formation of inactive metabolites that are excreted by the kidneys. T½ – 1 hour.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Pregnancy use