Allopurinol, tablets 100 mg 50 pcs

A drug that disrupts uric acid synthesis. It is a structural analog of hypoxanthine. It inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthine into xanthine and xanthine into uric acid. < br>

This results in a decrease in the concentration of uric acid and its salts in the body fluids and urine, which promotes the dissolution of existing urate deposits and prevents their formation in the tissues and kidneys. Taking allopurinol increases urinary excretion of hypoxanthine and xanthine.

< b>Pharmacokinetics

After oral administration, it is almost completely (90%) absorbed from the GI tract. < br>

Metabolized to form alloxanthin, which retains the ability to inhibit xanthine oxidase for quite a long time. < br>

Cmax of allopurinol in plasma is reached on average in 1.5 h, alloxanthin – in 4.5 h after a single dose.

T1/2 of allopurinol is 1-2 hours, of alloxantine about 15 hours. About 20% of the dose taken is excreted through the intestine, the rest through the kidneys.

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Indications

Active ingredient

Composition

1 tablet contains 100 mg allopurinol;

auxiliary ingredients:

lactose,

starch,

polyvidone,

talc,

magnesium stearate,

sodium amylopectin glycolate.

How to take, the dosage

The dosage of Allopurinol is set individually, controlling the concentration of uric acid in blood and urine.

The drug is taken with plenty of water. In adults with a mild course of disease 100-200 mg/day, with moderate disease 300-600 mg/day, with a severe course 700-900 mg/day.

In children under 15 years of age 10-20 mg/kg of body weight per day. The frequency of administration is 1-2 times a day.

Interaction

Allopurinol increases the effect of coumarin anticoagulants, adenine arabinoside, and hypoglycemic drugs (especially with impaired renal function) when used concomitantly.

Uricosuric agents and salicylates in high doses reduce the activity of allopurinol.

When using allopurinol and cytostatics concomitantly, myelotoxic effects are more common than when used separately.

In concomitant use of allopurinol and azathioprine or mercaptopurine, there is cumulation of the latter in the body because due to inhibition of xanthine oxidase activity required for biotransformation of the drugs by allopurinol, their metabolism and elimination slows down.

Special Instructions

When using the drug Allopurinol, daily fluid intake should be at least 2 liters (under the control of the daily amount of urine).

In the beginning of the treatment course an exacerbation of the disease may occur, for its prevention it is recommended to use anti-inflammatory drugs.

Allopurinol treatment may cause dissolution of large urinary stones and their subsequent passage into the urine. When combined use the drug increases the effect, in high doses it reduces the activity of the drug.

Contraindications

Side effects

Overdose

Symptoms: nausea, vomiting, diarrhea, dizziness, oliguria.

Treatment: forced diuresis, hemo- and peritoneal dialysis.

Similarities