Allopurinol-Egis, tablets 300 mg 30 pcs
€1.00
Out of stock
(E-mail when Stock is available)
A drug that disrupts uric acid synthesis.
Allopurinol is a structural analog of hypoxanthine.
Inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthine to xanthine and xanthine to uric acid.
This results in decreased concentration of uric acid and its salts in the body fluids and urine, which promotes the dissolution of existing urate deposits and prevents their formation in the tissues and kidneys.
Allopurinol administration increases urinary excretion of hypoxanthine and xanthine.
Indications
Treatment and prevention of gout and hyperuricaemia of any genesis (including in combination with nephrolithiasis, renal failure, urate nephropathy).
Recurrent mixed oxalate-calcium kidney stones in the presence of hyperuricosuria.
Elevated urate formation due to enzyme disorders.
Prevention of acute nephropathy in cytostatic and radiation therapy of tumors and leukemia, as well as in complete therapeutic fasting.
Active ingredient
Composition
1 tablet contains 100 mg allopurinol;
Additional ingredients:
Lactose,
Starch,
Polyvidone,
talc,
magnesium stearate,
sodium amylopectin glycolate.
How to take, the dosage
Dosing regimen of Allopurinol-Egis is established individually, under control of urate and uric acid concentrations in blood and urine.
Adults when taken orally – 100-900 mg/day, depending on the severity of the disease. Frequency of intake is 2-4 times per day after meals.
In children under 15 years of age 10-20 mg/kg/day or 100-400 mg/day.
Maximum dose: in kidney function disorders (including those caused by urate nephropathy) – 100 mg/day.
Lengthening of the dose is possible in cases when with the background of the current therapy there are still high concentrations of urate in blood and urine.
Interaction
Allopurinol increases the effect of coumarin anticoagulants, adenine arabinoside, and hypoglycemic drugs (especially with impaired renal function) when used concomitantly.
Uricosuric agents and salicylates in high doses reduce the activity of allopurinol.
When using allopurinol and cytostatics concomitantly, myelotoxic effects are more common than when used separately.
In concomitant use of allopurinol and azathioprine or mercaptopurine, there is cumulation of the latter in the body because due to inhibition of xanthine oxidase activity required for biotransformation of the drugs by allopurinol, their metabolism and elimination slows down.
Special Instructions
The daily amount of fluid intake is at least 2 liters.
Patients with tumor disease should be given a minimum dose before starting treatment with cytostatics.
In the beginning of gout treatment, an exacerbation of the disease may occur.
Please note that large urate stones may dissolve in the renal pelvis and then enter the ureter.
Contraindications
Developed liver and/or kidney function abnormalities, pregnancy, lactation.
High sensitivity to allopurinol.
Side effects
Possible nausea, diarrhea, skin rashes, fever.
Overdose
Symptoms: nausea, vomiting, diarrhea, dizziness, oliguria.
Treatment: forced diuresis, hemo- and peritoneal dialysis.
Similarities
Weight | 0.049 kg |
---|---|
Shelf life | 5 years |
Conditions of storage | Store in a light-protected place at a temperature not exceeding 30 ° C. . |
Manufacturer | EGIS, Hungary |
Medication form | pills |
Brand | EGIS |
Related products
Buy Allopurinol-Egis, tablets 300 mg 30 pcs with delivery to USA, UK, Europe and over 120 other countries.