Albumin, 20% 100 ml

Human albumin

Indications

A decrease in plasma albumin concentration of less than 30 g/l or colloid-oncotic pressure of less than 15 mm Hg, or a decrease in total protein of less than 50 g/l:

hypoalbuminemia of various origins – shock (hemorrhagic, traumatic, thermal), acute blood loss (decrease in blood volume by more than 25-30%), purulent-septic conditions, liver diseases with impaired albumin-synthesizing function, kidney diseases (nephritis, nephrotic syndrome), burn disease;

operations using artificial circulation;

therapeutic plasmapheresis;

hemolytic disease of newborns during exchange transfusion;

carrying out preoperative hemodilution and procurement of autologous blood components;

cerebral edema (hyperoncotic solutions);

gastrointestinal diseases with impaired absorption or patency.

Pharmacological effect

Pharmaceutical group: plasma replacement agent.

Pharmaceutical action:

A plasma replacement agent obtained by fractionating human plasma.

Replenishes plasma albumin deficiency, maintains colloid-osmotic (oncotic) blood pressure, quickly increases blood pressure and blood volume, increases the transition and promotes retention of tissue fluid in the bloodstream, increases reserves of protein nutrition of tissues and organs.

Special instructions

Before using the drug, the doctor records the label data (name of the drug, manufacturer, batch number) in the patient’s medical history.

In the elderly, rapid administration of a 10% albumin solution should be avoided, as this can lead to overload of the cardiovascular system.

Albumin solutions should be warmed to room temperature before infusion. The drug is not suitable for use in containers with damaged integrity or labeling, if the physical properties have changed (color change, clouding of the solution, presence of suspension, sediment), if the expiration date has expired, or improper storage.

Active ingredient

Human albumin

Composition

1 ml of solution for infusion contains:

Active ingredient:

human albumin 100 mg;

Excipients:

sodium caprylic acid,

sodium chloride,

water for injections.

Pregnancy

During pregnancy, the use of human albumin is possible only in cases of extreme necessity.

Contraindications

Hypersensitivity.
Severe forms of heart failure (due to the possible occurrence of acute heart failure).
Thrombosis.
Severe form of arterial hypertension.
Ongoing internal bleeding.
Hypervolemia.
Pulmonary edema.
Severe anemia.
Brain swelling.

Prescribed with caution for: renal failure, bronchial asthma, allergic rhinitis, Quincke’s edema.

Side Effects

The administration of a 10% albumin solution, as a rule, is not accompanied by adverse reactions and complications; sometimes the development of:

Allergic reactions of varying severity (urticaria and others).
Hyperthermia.
Pain in the lumbar region.

Interaction

With simultaneous use of albumin with ACE inhibitors, the risk of developing arterial hypotension increases.

Overdose

In case of an overdose or too rapid administration of the drug, hypervolemia may occur (development of pulmonary edema, increased arterial and central venous pressure).

At the initial signs of an anaphylactic reaction or signs of an overdose (headache, shortness of breath, suffocation), the albumin transfusion should be stopped immediately and, without removing the needle from the vein, appropriate drugs should be administered (glucocorticosteroids, vasopressors if indicated).

Storage conditions

In a dry place, protected from light, at a temperature of 2-10 °C.

Shelf life

5 years. Do not use after expiration date.

Manufacturer

Ivanovo blood transfusion station OBUZ, Russia