Akriderm Genta, ointment 15 g

Acriderm GENTA is a combination drug for external use with anti-inflammatory, anti-allergic and antibacterial effects.

Betamethasone dipropionate is a glucocorticosteroid with anti-inflammatory, anti-allergic, anti-exudative, anti-edema and antipruritic effect. It inhibits leukocyte accumulation, release of lysosomal enzymes and proinflammatory mediators in the inflammation focus, inhibits phagocytosis, decreases vascular and tissue permeability and prevents inflammatory edema formation.

Gentamicin is a broad-spectrum antibiotic of aminoglycoside group. It has a bactericidal effect against pathogens of primary and secondary bacterial skin infections.

Active against Gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; against Gram-positive bacteria: Streptococcus spp. (sensitive strains of beta- and alpha-hemolytic Streptococcus group A), Staphytococcus spp. (coagulase-positive, coagulase-negative and some strains producing penicillinase). It is inactive against anaerobes, fungi and viruses.

Indications

Treatment of steroid-sensitive dermatoses complicated by primary and/or secondary bacterial infection, eczema (atopic, childhood, coin-shaped), limited and diffuse allergic dermatoses, including complicated by infection sensitive to gentamicin, dermatitis (simple and allergic), atopic dermatitis, solar dermatitis, exfoliative and radiation dermatitis, diaper rash, psoriasis, itching.

Pharmacological effect

Akriderm GENTA is a combined preparation for external use that has anti-inflammatory, antiallergic and antibacterial effects.

Betamethasone dipropionate is a glucocorticosteroid that has anti-inflammatory, antiallergic, antiexudative, decongestant and antipruritic effects. Inhibits the accumulation of leukocytes, the release of lysosomal enzymes and pro-inflammatory mediators at the site of inflammation, inhibits phagocytosis, reduces vascular tissue permeability, and prevents the formation of inflammatory edema.

Gentamicin is a broad-spectrum antibiotic from the aminoglycoside group. Has a bactericidal effect against pathogens of primary and secondary bacterial skin infections.

Active against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp. (susceptible strains of group A beta- and alpha-hemolytic streptococcus), Staphytococcus spp. (coagulase-positive, coagulase-negative and some penicillinase-producing strains). Inactive against anaerobes, fungi and viruses.

Special instructions

The drug is not used in ophthalmology. Avoid contact of the cream with the eyes, damaged skin and open wound areas. In order to increase the effectiveness of therapy, it is possible to use occlusive dressings.

It must be taken into account that this increases the transdermal absorption of betamethasone and gentamicin, which leads to an increased risk of developing systemic side effects. If resistant bacterial or fungal microflora appears, use of the drug should be discontinued and appropriate therapy should be prescribed. the development of cross-resistance with aminoglycoside antibiotics is possible.

Active ingredient

Betamethasone, Gentamicin

Composition

1 gram contains 0.64 mg of betamethasone dipropionate (equivalent to 0.5 mg of betamethasone) and gentamicin sulfate – 1 mg.

Pregnancy

Perhaps, if the expected effect of therapy for the mother exceeds the potential risk to the fetus.

Contraindicated during pregnancy in large doses and for a long time.

Breastfeeding should be stopped during treatment.

Contraindications

Hypersensitivity to the components of the drug.

Skin tuberculosis, viral skin infections, vaccinations, perioral dermatitis, rosacea (rosacea).

Side Effects

Burning, dry skin, folliculitis, hypertrichosis, hypopigmentation, allergic contact dermatitis, skin atrophy, stretch marks, prickly heat.

Interaction

No interactions of the drug with other drugs have been identified.

Overdose

Acute overdose is unlikely, however, with excessive or prolonged use of the drug, chronic overdose is possible, accompanied by signs of hypercortisolism: hyperglycemia, glycosuria, reversible inhibition of adrenal function, manifestation of Cushing’s syndrome.

Treatment. Appropriate symptomatic treatment is indicated. In case of chronic toxic effects, gradual withdrawal of the drug is recommended.

Storage conditions

At 15–25 °C

Shelf life

2 years

Manufacturer

Akrikhin JSC, Russia