Akriderm, 0.05% cream 30 g

Pharmgroup:

Glucocorticosteroid for topical use.

Pharmic action:

The corticosteroid betamethasone dipropionate has anti-inflammatory, anti-allergic, anti-exudative, anti-edema and antipruritic effects.

Inhibits leukocyte accumulation, release of lysosomal enzymes and anti-inflammatory mediators in the inflammation focus, inhibits phagocytosis, reduces vascular and tissue permeability and prevents formation of inflammatory edema.

Indications

Allergic skin diseases (including acute, subacute and chronic contact dermatitis, occupational dermatitis, seborrheic dermatitis, atopic dermatitis, sun dermatitis, neurodermitis, skin itching, dyshydrotic dermatitis, eczema);

acute and chronic forms of non-allergic dermatitis;

psoriasis.

Active ingredient

Composition

1 g:

– betamethasone dipropionate 0.64 mg;

supplements:

methylparahydroxybenzoate (nipagin),

paraffin,

Vaseline,

propylene glycol,

vaseline oil,

emulsifying wax,

dinatrium edetate (trilon B),

How to take, the dosage

Externally. Acriderm® is applied thinly to the affected area of the skin twice a day – in the morning and in the evening. Other frequency of application can be determined by a doctor, depending on the severity of the disease. In mild cases, it is usually enough to use once a day; more frequent application might be necessary.

The duration of treatment depends on the effectiveness and tolerability of the therapy and is 2-4 weeks.

If clinical improvement does not occur, the diagnosis needs to be clarified.

Interaction

Acriderm does not interact with other medicines.

Special Instructions

If there are signs of hypersensitivity or skin irritation associated with the use of the drug, treatment should be discontinued and the patient should find an adequate therapy. During prolonged treatment, when applying the drug to large surfaces of the skin, when using occlusive dressings, as well as in children, systemic absorption of glucocorticosteroids is possible.

In children from 1 year of age the drug is prescribed only with strict indications and under medical supervision, because of possible systemic side effects associated with betamethasone. When using the drug on large surfaces and/or under occlusive dressing suppression of hypothalamic-pituitary-adrenal system function and development of hypercorticism symptoms may occur, reduction of growth hormone excretion and increased intracranial pressure may be observed.

Atrophic changes may occur on the skin of the face more frequently than on other body surfaces after long-term treatment with topical glucocorticosteroids; in this case the course of treatment should not exceed 5 days.

Acriderm® cream is not suitable for use in ophthalmology. Avoid contact with the eyes.

Long-term use of the drug should be discontinued gradually.

Contraindications

Hypersensitivity to any of the ingredients of the drug, bacterial, fungal skin diseases, skin tuberculosis, cutaneous syphilis, varicella, herpes simplex, skin postvaccinal reactions, open wounds, trophic ulcers of the shin, rosacea, acne vulgaris, skin cancer, nevi, atheroma, melanoma, hemangioma, xanthoma, sarcoma, lactation and children under 1 year old.

With caution

Pregnancy. With long-term use or application on large surfaces: cataracts, diabetes mellitus, glaucoma, tuberculosis.

Side effects

When using glucocorticosteroids topically there may be: burning, irritation, dry skin, folliculitis, hypertrichosis, acne-like rashes, skin itching, stretch marks, sweating, hypopigmentation, perioral dermatitis.

Long-term use or use of occlusive dressings causes skin maceration, secondary infection, skin atrophy, sweating, purpura, local hirsutism and telangiectasia.

When applied to large body surfaces, mainly in children systemic side effects of glucocorticosteroids may occur (gastritis, ulceration of mucosa of the gastrointestinal tract, hyperglycemia, glucosuria, reversible suppression of adrenal cortical function, manifestation of Cushing’s syndrome).

In case of any adverse reactions not described in the instructions, consult a physician.

Overdose

Acute overdose is unlikely; however, with excessive or prolonged use of the drug, chronic overdose is possible, accompanied by signs of hypercorticism: hyperglycemia, glucosuria, reversible suppression of adrenal cortical function, manifestation of Cushing’s syndrome.

Treatment. Appropriate symptomatic treatment is indicated. In case of chronic toxic effects, gradual withdrawal of the drug is recommended.

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