Aertal, 100 mg 60 pcs.

Pharmacodynamics:
Aceclofenac is a non-steroidal compound with anti-inflammatory and analgesic effect. Its mechanism of action is based on inhibition of prostaglandin synthesis.

Pharmacokinetics:
Absorption

Aceclofenac is rapidly absorbed after oral administration, bioavailability is almost 100%. Maximal concentration in blood plasma is reached 1.25-3 hours after intake. Simultaneous intake of food slows absorption, but does not affect its degree.

Distribution

Aceclofenac is highly bound to plasma proteins (>99.7%). Aceclofenac penetrates into the synovial fluid, where its concentration reaches 60% of its concentration in plasma. The volume of distribution is about 30 liters.

Metabolism

Aceclofenac is believed to be metabolized by the CYP2C9 isoenzyme. The main metabolite is 4-ONE-acetylophenac, which probably has minimal clinically significant effects. Various metabolites (including diclofenac and 4- OH-diclofenac) have been found.

Excretion

The average elimination half-life (t1/2) is 4-4.3 hours. Clearance is 5 l/h. About 2/3 of the dose taken is excreted by the kidneys, mainly as conjugated hydroxymetabolites. Only 1% of the dose after oral administration is excreted unchanged.

Pharmacokinetics in special groups of patients

Elderly patients (over 65 years)

Pharmacokinetics of aceclofenac in elderly patients is not changed.

Patients with hepatic impairment

A slower excretion of aceclofenac was observed in patients with moderate hepatic function after single administration of the drug. In a multiple-dose study, there were no differences in pharmacokinetic parameters between participants with mild to moderate liver cirrhosis and healthy volunteers when aceclofenac was administered 100 mg once daily.

Patients with renal impairment

No clinically significant differences in pharmacokinetic parameters were observed in patients with renal impairment of mild to moderate severity after a single dose compared to healthy volunteers.

Indications

Active ingredient

Composition

How to take, the dosage

Special Instructions

Contraindications

Side effects

Overdose

Pregnancy use

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