Adaklin, cream 1 mg/g 30 g
€19.85 €17.21
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Adaklin is a drug for external use. Adapalene is a metabolite of retinoid, has a comedolytic and anti-inflammatory effect, normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific gamma-receptors of epidermal skin cells.
As a result of the action of adapalene, in particular, the “adhesion” of epithelial cells at the mouth of the follicle and the reduction of preconditions for the formation of microcomedones. Adapalene has an anti-inflammatory effect in vitro and in vivo, affecting inflammatory factors by inhibiting the migration of leukocytes in the inflammation focus and metabolism of arachidonic acid.
Absorption: absorption of adapalene through the skin is very low (about 4% of the administered dose). Excretion: excretion of adapalene from the body occurs mainly with bile.
Indications
Acne.
Pharmacological effect
Adaklin is a drug for external use. Adapalene is a retinoid metabolite, has comedolytic and anti-inflammatory effects, normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific gamma receptors of epidermal skin cells.
As a result of the action of adapalene, in particular, there is a decrease in the “adhesion” of epithelial cells at the mouth of the pilosebaceous follicle and a decrease in the prerequisites for the formation of microcomedones. Adapalene has an anti-inflammatory effect in vitro and in vivo, affecting inflammatory factors by inhibiting the migration of leukocytes at the site of inflammation and the metabolism of arachidonic acid.
Absorption: Absorption of adapalene through the skin is very low (about 4% of the applied dose). Excretion: excretion of adapalene from the body occurs mainly with bile.
Special instructions
If the drug accidentally gets on the mucous membranes of the eyes, mouth or nose, rinse them thoroughly with warm water. Direct sunlight should be avoided as skin irritation may occur. Treatment can be continued if sun exposure is kept to a minimum by wearing sunglasses and hats.
The simultaneous use of cosmetics with a drying and irritating effect on the skin (for example, perfumes or ethanol-containing products) is not recommended. Adapalene applied to the skin in the evening can be combined with acne medications used in the morning.
Active ingredient
Adapalene
Composition
Active ingredient:
adapalene 1 mg.
excipients:
methyldextrose stearate 35 mg,
macrogol (20) 35 mg,
squalane (natural) 60 mg,
methyl parahydroxybenzoate 2 mg,
propyl parahydroxybenzoate 1 mg,
disodium edetate 1 mg,
phenoxyethanol 5 mg,
glycerol 30 mg,
carbomer (934P) 4 mg,
cyclomethicone 130 mg,
sodium hydroxide 0.5 mg.
Contraindications
Hypersensitivity to the components of the drug Adaklin;
pregnancy;
lactation period (breastfeeding);
children under 12 years of age.
With caution: the drug should be used with caution for dermatitis, eczema, seborrhea.
Side Effects
Dermatological reactions: skin irritation, hyperemia and peeling of the skin at the site of application (treatment should be suspended until the skin irritation disappears or the frequency of use should be reduced).
Interaction
Since adapalene does not interact with oxygen and is not destroyed by light, simultaneous treatment of acne with drugs such as clindamycin or benzoyl peroxide is possible.
Storage conditions
At a temperature not exceeding 25 °C
Shelf life
2 years
Manufacturer
Sun Pharmaceutical Industries Ltd, India
Shelf life | 2 years |
---|---|
Conditions of storage | At a temperature not exceeding 25 °C |
Manufacturer | Sun Pharmaceutical Industries Ltd, India |
Medication form | exterior cream |
Brand | Sun Pharmaceutical Industries Ltd |
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