Adaklin, cream 1 mg/g 30 g

Adaklin is a drug for external use. Adapalene is a metabolite of retinoid, has a comedolytic and anti-inflammatory effect, normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific gamma-receptors of epidermal skin cells.

As a result of the action of adapalene, in particular, the “adhesion” of epithelial cells at the mouth of the follicle and the reduction of preconditions for the formation of microcomedones. Adapalene has an anti-inflammatory effect in vitro and in vivo, affecting inflammatory factors by inhibiting the migration of leukocytes in the inflammation focus and metabolism of arachidonic acid.

Absorption: absorption of adapalene through the skin is very low (about 4% of the administered dose). Excretion: excretion of adapalene from the body occurs mainly with bile.

Indications

Ugric acne.

Active ingredient

Composition

Active ingredient:

auxiliary substances:

methyldextrose stearate 35 mg,

macrogol (20) 35 mg,

squalane (natural) 60 mg,

methyl parahydroxybenzoate 2 mg,

propyl parahydroxybenzoate 1 mg,

dinatrium edetate 1 mg,

phenoxyethanol 5 mg,

glycerol 30 mg,

How to take, the dosage

Externally. Before applying the cream it is necessary to clean and dry the skin of the face.

With a light touch, apply the cream evenly to the affected surface once a day before going to bed, avoiding contact of the drug with the mucous membranes of the eyes and lips.

Therapeutic effect is seen after 4-8 weeks of treatment; long-term improvement occurs after 3 months of treatment.

In some cases due to transient skin irritation the treatment may be suspended until the signs of irritation disappear.

Retreatment is possible after consultation with a physician.

Interaction

Because adapalene does not interact with oxygen and is not destroyed by light, drugs such as clindamycin or benzoyl peroxide can be used at the same time to treat acne.

Special Instructions

In case of accidental contact of the drug with the mucous membranes of the eyes, mouth or nose, rinse them thoroughly with warm water. Direct sunlight should be avoided as skin irritation may occur. Treatment may continue if sun exposure is minimized through the use of sunglasses and hats.

The simultaneous use of cosmetic products with a drying and irritating effect on the skin (e.g., perfumes or ethanol-containing products) is not recommended. Adapalene applied to the skin in the evening may be combined with acne medications applied in the morning.

Contraindications

With caution: the drug should be used with caution in cases of dermatitis, eczema, seborrhea.

Side effects

Dermatological reactions: skin irritation, hyperemia and peeling of the skin at the application site (treatment should be stopped until the skin irritation disappears or the frequency of use is reduced).

Similarities