Acyclovir forte, tablets 400 mg 20 pcs

Antiviral drug, synthetic analog of acyclic purine nucleoside, which has a highly selective effect on herpes viruses. A series of sequential reactions of acyclovir transformation into mono-, di- and triphosphate acyclovir takes place inside the virus-infected cells under the action of viral thymidine kinase. Acyclovir triphosphate integrates into the chain of viral DNA and blocks its synthesis by competitive inhibition of viral DNA polymerase.

Indications

Active ingredient

How to take, the dosage

Interaction

Concomitant use with probenecid increases the average half-life and decreases the clearance of acyclovir.

Concomitant use with nephrotoxic drugs increases the risk of renal dysfunction.

Special Instructions

Contraindications

Side effects

Overdose

Ingestion of 20 g of acyclovir has been reported. Symptoms: agitation, coma, convulsions, lethargy. Precipitation of acyclovir in the renal tubules is possible if its concentration exceeds renal tubule solubility (2.5 mg/ml).

Parenteral overdose (when given by bolus injection, or when used in high doses, or in patients whose water-electrolyte balance was not properly controlled): increased urea nitrogen, hypercreatininemia, renal dysfunction, lethargy, seizures, coma.

Treatment: maintenance of vital functions, hemodialysis.

Pregnancy use

Acyclovir penetrates the placental barrier and accumulates in breast milk.

The use during pregnancy is possible only if the estimated benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to take acyclovir during lactation, interruption of breastfeeding is required.

Similarities