Actitropil, tablets 100 mg 30 pcs

Pharmacotherapeutic group: nootropic agent.

ATX code: N06BX

Pharmacological properties

Pharmacodynamics

A nootropic medicine with a pronounced anti-amnesic effect, direct activation of integrative activity of the brain, promotes memory consolidation, improves concentration and mental performance, facilitates learning, increases the speed of information transfer between the cerebral hemispheres, increases resistance of brain tissue to hypoxia and toxic effects, has anticonvulsant and anxiolytic activity, regulates the processes of activation and inhibition of the central nervous system, improves the blood circulation in the brain and brain tissue.

It has a positive effect on metabolic processes and blood circulation in the brain, stimulates redox processes, increases the body’s energy potential by utilizing glucose, improves regional blood flow in ischemic brain areas. Increases the content of noradrenaline, dopamine and serotonin in the brain, does not affect the level of GABA, does not bind to either GABA_A or GABA_B receptors, has no noticeable effect on spontaneous bioelectrical activity of the brain.

It has no effect on respiration and cardiovascular system, shows a subtle diuretic effect, has anorexigenic activity when used as a course.

The stimulant action is manifested by its ability to produce a moderately pronounced effect on motor reactions, increased physical performance, a pronounced antagonism to the cataleptic action of neuroleptics, and a decrease in the severity of the sleeping effect of ethanol and hexenal.

The psychostimulant effect is predominant in the ideational sphere.

Moderate psychostimulant effect of the drug is combined with anxiolytic activity, improves mood, has some analgesic effect, increasing the threshold of pain sensitivity.

The adaptogenic effect is shown in increasing the body’s resistance to stress under conditions of excessive mental and physical exertion, fatigue, hypokinesia and immobilization, at low temperatures.

An improvement of vision was noted during taking, which is manifested by an increase in the acuity, brightness and visual fields.

It improves blood supply to the lower extremities.

Stimulates the production of antibodies in response to antigen introduction, which indicates its immunostimulatory properties, but at the same time it does not promote immediate-type hypersensitivity and does not change the allergic inflammatory skin reaction caused by the introduction of a foreign protein.

The drug does not develop drug dependence, tolerance or withdrawal syndrome when used with a course of treatment.

The action starts with a single dose, which is important when using the drug in extreme conditions.

It does not have teratogenic, mutagenic, carcinogenic and embryotoxic properties. Toxicity is low, the lethal dose in an acute experiment is 800 mg/kg.

Pharmacokinetics

absorption

It is rapidly absorbed, penetrates various organs and tissues, and easily passes through the blood-brain barrier.

Distribution

absolute bioavailability when taken orally is 100%. Maximal concentration in blood (Т_max) is reached after 1 hour, the half-life (Т_1/2) – 3 – 5 h.

Metabolism

Not metabolized in the body.

Evolution

It is excreted unchanged: about 40% – with urine and 60% – with bile and sweat.