Acesol, 200 ml

Pharmgroup:

Rehydrating agent.

Pharmaceutical action:

Acesol is a combined drug, has detoxifying, plasma exchange, rehydration, diuretic, antishock, antiaggregant action.

It reduces hypovolemia, prevents blood clotting and development of metabolic acidosis, increases diuresis and improves microcirculation.

Indications

Active ingredient

Composition

1 liter:

– sodium acetate 2 g

– sodium chloride 5 g

– potassium chloride 1 g

How to take, the dosage

The drug Atsesol is used only in moderate and severe conditions when it is impossible to take solutions for oral rehydration, administered intravenously by jetting (1-3 hours).

Before administration the solution is heated to 36-38 ° C. The volume of the administered solution is chosen individually in such quantity which is necessary for restoration of water-electrolyte balance (if the patient has severe forms of diseases the solution is given by trickle in amount corresponding to 7-10% of the body weight during 1 hour; afterwards the trickle administration is replaced by dropwise administration with the rate of 40-120 drops/min (24-48 hours)) with control of laboratory indices.

The balance of injected and lost fluids is determined every 6 hours. The total amount of solution administered should correspond to the volume of fluid excreted with feces, vomit, urine and sweat.

Interaction

If necessary, it may be combined with an infusion of blood, plasma, polyglucin, etc.

Special Instructions

Treatment is carried out under control of hematocrit and blood electrolyte concentration.

In case of hyperkalemia the drug is replaced with Disol solution until normalization of electrolyte balance.

Freezing of the drug is not a contraindication to its use.

The non-wetting of the inner surface of the bottle or polymeric container is not a contraindication for the use of the drug.

Influence on driving and operating machinery

There have been no studies to evaluate the effect of the drug on the ability to drive vehicles and perform other potentially dangerous activities requiring increased concentration and quick psychomotor reactions. In general case of dehydration it is indicated to administer special solutions orally, but only if it is impossible (uncontrollable vomiting, severe degree of dehydration, severe general condition, etc.) the drug is administered parenterally.

Contraindications

With caution in patients with impaired renal excretory function.

Perhaps in patients with impaired renal function

Perhaps with caution in patients with impaired renal excretory function.

Contraindicated in chronic renal insufficiency.

Side effects

Overdose

Symptoms: in patients with chronic kidney disease or any disease accompanied by impaired potassium excretion, or if the drug is administered too rapidly by IV, hyperkalemia may develop, which may potentially be fatal. Early clinical manifestations of hyperkalemia (sharpening of P wave, disappearance of U wave, lowering of ST segment and prolongation of QT interval) usually appear at serum potassium concentration of 7 to 8 mEq/l. More severe symptoms (including muscle paralysis and cardiac arrest) develop at a potassium concentration of 9 to 10 mEq/L. Note that fatal hyperkalemia may develop rapidly and be asymptomatic.

Treatment: the drug is withdrawn; if hyperkalemia occurs the drug is replaced with “Disol” solution until normalization of electrolyte balance. If necessary hemodialysis and peritoneal dialysis are carried out.