🐾 Serenia solution for injection, 20 ml

Serenia belongs to the group of antiemetics.

The active substance of Serenia – maropitant citrate – is an antagonist of neurokinin receptors (NK1) and inhibits the binding of substance P, a tachykinin group neutropeptide in the CNS. Maropitant citrate is effective for vomiting of both central and peripheral genesis. Maropitant is rapidly absorbed from the injection site and reaches maximum plasma concentration 45 minutes after injection. Maropitant is more than 99% bound to plasma proteins.  The bioavailability of Serenia is 90%. Maropitant is metabolized in liver by cytochrome P450, excreted mainly with feces.

By the degree of impact on the body Maropitant citrate refers to moderately hazardous substances (3rd class of hazard according to GOST 12.1.007-76).

Special instructions

No specific effects were identified upon initiation and discontinuation of the drug.
Omissions should be avoided when administering the next dose of the drug, as this may lead to a decrease in effectiveness. If one dose is missed, the course of treatment should be resumed in the doses and dosage regimen prescribed in the instructions.
The medicinal product is not intended for use in productive animals.
Empty drug bottles must not be used for household purposes; they must be disposed of with household waste.

Side Effects

When using Serenia in accordance with the instructions, there are usually no side effects or complications. If allergic reactions occur, stop using the drug and prescribe antihistamines and symptomatic treatment. When administered, a painful reaction is possible, especially in cats.

Contraindications

The use of the drug in dogs under 8 weeks of age, cats under 16 weeks of age and animals with increased individual sensitivity to the components of the drug is prohibited.
The drug should be prescribed with caution to animals with liver pathology and in cases of heart failure. The drug is not recommended for use by pregnant and lactating females.

Active ingredient

Maropitant

Interaction

Serenia can be used as part of complex therapy with other pathogenetic agents. The drug should not be co-administered with calcium channel blockers as maropitant has an affinity for calcium channels. Maropitan may compete with drugs that are highly bound to plasma proteins.

Manufacturer

Zoetis, Spain

Shelf life

The shelf life of the medicinal product, subject to storage conditions, is 3 years from the date of manufacture. After selecting part of the drug from the bottle, subject to aseptic rules and specified storage conditions, it can be used repeatedly for 90 days.