🐾 Apoquel tablets 16 mg, 20 pcs.

Apoquel belongs to the group of selective Janus Kinase Inhibitors (JAK) drugs.

Oclacitinib maleate, a component of the drug, inhibits the functions of proinflammatory, proallergic and pruritogenic (pruritogenic) cytokines dependent on the enzymatic activity of Janus Kinase JAK1 or JAK3 at therapeutic dose, the targeted effect on which allows inhibiting key mechanisms of allergy-related itching and helps to eliminate the symptoms of local inflammation; cytokines involved in hematopoiesis and dependent on JAK2 are not significantly affected.

After oral administration oclacytinib maleate is quickly absorbed in gastro-intestinal tract (bioavailability is 89 %), enters systemic blood flow, maximum concentration in plasma is reached in less than 1 hour, penetrates into most organs and tissues, is practically not metabolized, excreted unchanged, mainly with urine, elimination half-life is 3-4 hours.

Apokvel is classified as moderately hazardous substances (3 class of hazard according to GOST 12.1.007) with weakly expressed cumulative properties; in recommended dose it does not exhibit mutagenic, carcinogenic, embryotoxic and teratogenic activity.

Indications

Active ingredient

Composition

How to take, the dosage

Special Instructions

Contraindications

Side effects