Ventolin, aerosol 100 mcg/dose 200 doses
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Salbutamol is a selective agonist of b2-adrenoreceptors.
In therapeutic doses, it acts on b2-adrenoceptors of bronchial smooth muscle, with little or no effect on myocardial b1-adrenoceptors.
Bronchial asthma, Bronchospasm, Chronic Obstructive Pulmonary Disease
– relief of bronchial asthma attacks, including an exacerbation of severe bronchial asthma;
. – Prevention of bronchospasm attacks, associated with exposure to allergens or caused by physical activity.
– Use as a component of long-term maintenance therapy of bronchial asthma.
Chronic obstructive pulmonary disease (COPD) accompanied by reversible airway obstruction, including chronic bronchitis and pulmonary emphysema.
One dose contains 100 mcg of salbutamol (in the form of salbutamol sulfate).
How to take, the dosage
Ventolin metered dose aerosol is intended for inhalation administration only.
The question of increasing the dose or frequency of use of the drug can only be decided by your doctor.
The use of Ventolin inhaler more than 4 times a day is not recommended. The need for frequent use of maximum doses of Ventolin or a sudden increase in dose suggests a worsening of the course of the disease.
Adults (including elderly patients)
Cure bronchospasm attack: the recommended dose is 100-200 mcg (1-2 inhalations).
Preventing attacks of bronchospasm associated with exposure to an allergen or caused by physical activity: The recommended dose is 200 mcg (2 inhalations) 10-15 minutes before exposure to the triggering factor.
Long-term maintenance therapy: the recommended dose is up to 200 mcg (2 inhalations) 4 times a day. Ventolin can be administered via a ‘Volumatic’ spacer.
To relieve an attack of bronchospasm: the recommended dose is 100-200 mcg (1-2 inhalations).
Preventing attacks of bronchospasm associated with exposure to an allergen or caused by physical activity: the recommended dose is 100-200 mcg (1-2 inhalations) 10-15 minutes before exposure to the provocative factor.
Long-term maintenance therapy: the recommended dose is up to 200 mcg (2 inhalations) 4 times a day. Ventolin can be administered through a ‘Babyhaler’ or ‘Volumatic’ spacer.
The simultaneous use of salbutamol and non-selective b-adrenoceptor blockers, such as propranolol, is not recommended.
Salbutamol is not contraindicated in patients receiving monoamine oxidase inhibitors (MAOIs).
Salbutamol should be used with caution in patients with thyrotoxicosis. Therapy with b2-adrenoceptor agonists, especially when administered parenterally or with a nebulizer, may lead to hypokalemia.
Particular caution is recommended when treating severe attacks of bronchial asthma because in these cases hypokalemia may increase as a result of simultaneous use of xanthine derivatives, glucocorticosteroids, diuretics, as well as due to hypoxia. In such situations it is necessary to monitor serum potassium level.
Patients should be instructed on the proper use of the Ventolin inhaler. Bronchodilators should not be the sole or main component of therapy for unstable or severe bronchial asthma.
If the usual dose of Ventolin becomes less effective or lasts less long (the action of the drug must last at least 3 hours), the patient should see a physician.
An increased need for short-acting inhaled b2-adrenoceptor agonists to control bronchial asthma symptoms indicates an exacerbation of the disease. In such cases, the patient’s treatment plan should be reconsidered.
The sudden and progressive worsening of bronchial asthma may be life-threatening for the patient, so in such situations it is necessary to urgently address the issue of prescribing or increasing the dose of glucocorticosteroids. Daily monitoring of peak expiratory velocity is recommended in such patients.
High doses of salbutamol can cause adverse reactions; therefore, only your physician can decide whether to increase the dose or frequency of use.
Patients using Ventolin Nebulas at home should be warned that if the effects of the usual dose become less effective or less prolonged, the dose or frequency of administration of the drug should not be increased independently, but should see a physician immediately.
Nebula Ventolin should be used with caution in patients who are already taking high doses of other sympathomimetics.
– Threatened abortion.
– Hypersensitivity to any component of the drug.
– Management of preterm labor.
– Childhood under 2 years of age.
Salbutamol may cause mild skeletal muscle tremor, which is usually most pronounced in the hands and is a characteristic side effect of all b2-adrenoreceptor agonists. Patients occasionally experience headache, peripheral vasodilation, and a slight compensatory increase in heart rate.
Very rarely hypersensitivity reactions (including angioedema, urticaria, bronchospasm, arterial hypotension and collapse), muscle cramps and tachycardia develop.
Inhaled drugs may cause paradoxical bronchospasm. Paradoxical bronchospasm should be treated immediately with another form of salbutamol or another rapid-acting inhaled bronchodilator. The use of Ventolin inhaler should be stopped immediately, the patient’s condition should be evaluated, the necessary examination should be performed, and appropriate therapy should be prescribed.
Inhaled drugs may cause irritation of the mucous membrane of the mouth and pharynx.
Therapy with beta2-adrenoreceptor agonists sometimes causes hypokalemia, which can be very dangerous for the patient.
Like other beta2-adrenoreceptor agonists, salbutamol may occasionally cause mental agitation and increased motor activity in children.
In patients with a predisposition to develop arrhythmias, salbutamol may cause cardiac rhythm disturbances, including atrial fibrillation, supraventricular tachycardia and extrasystoles.
In case of salbutamol overdose, the best antidotes are cardioselective b-adrenoblockers.
However, b-adrenoreceptor blockers should be used with caution in patients with a history of bronchospasm attacks.
The use of large doses of salbutamol may cause hypokalemia; therefore serum potassium levels should be monitored if overdose is suspected.
In lactation and pregnancy, the drug is prescribed only when the expected benefit to the mother exceeds any possible risk to the fetus.
Salbutamol is likely to penetrate into the breast milk, so breast-feeding women should not take it unless the expected benefit to the mother exceeds any potential risk to the baby.
It is not known whether salbutamol present in breast milk has any adverse effects on the newborn baby.
Salbutamol, Salbutamol-MCFP, Salbutamol-Pharmstandart, Novatron
|Conditions of storage|
In a light-protected place at a temperature not exceeding 30 °C (do not freeze or heat)
Glaxo Wellcome S.A., Spain
metered aerosol for inhalation
Glaxo Wellcome S.A.
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