Pharmacological action – analgesic, antipyretic, anti-inflammatory.
Methamisole (derivative of pyrazolone) has analgesic, antipyretic and mild anti-inflammatory effects, pitophenone has direct myotropic effect on smooth muscles, causing their relaxation, phenpiperinium has cholinolytic effect and consequently also relaxing effect on smooth muscles.
It relieves pain, eliminates spasm of smooth muscles, reduces elevated body temperature.
Painful menstruation (algodysmenorrhea), Biliary dyskinesia, Arthritis and arthritis, Headache, Pain after injuries and operations, Colic, Migraine, Sciatica, Lumbago, trigeminal neuralgia, Toothache
Sodium metamizole, Pitofenone, Phenpiperinia bromide
1 tablet contains:
Sodium metamizole 500 mg,
pitophenone hydrochloride 5 mg
phenpiperinium bromide 0.1 mg
Lactose, corn starch (anhydrous), povidone, methylhydroxybenzoate, purified talc, magnesium stearate.
How to take, the dosage
Ingestion, preferably after meals.
Adults: and children over 15 years of age take 1-2 tablets 2-3 times a day, the maximum daily dose of Bral is 6 tablets.
Children: only when prescribed by a physician: 6-8 years 1/2 tablet, 9-12 years – 3/4 tablet, 13-15 years – 1 tablet 2-3 times a day.
The duration of administration is not more than 5 days.
Simultaneous use of Bral with other non-narcotic analgesics may result in mutually reinforcing effects.
Tricyclic antidepressants, oral contraceptives, allopurinol impair metabolism of metamizole in the liver and increase its toxicity.
Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effects of sodium metamizole.
Simultaneous use with cyclosporine reduces the blood levels of the latter. Sedatives and tranquilizers increase the analgesic effect of the drug.
When co-administration with ethanol – mutual enhancement of the effects.
Physician should be consulted if it is necessary to use the above and other medicinal products at the same time.
Methamizole metabolites can stain urine red.
- ischemic heart disease
- adenoma of the prostate
- severe hepatic and renal failure
- high sensitivity to the components of the drug.
- Decrease in the number of white blood cells
- decrease in blood pressure
- disorders of kidney function
- allergic reactions.
Symptoms: confusion, liver and kidney dysfunction, nausea, vomiting, decreased blood pressure, drowsiness, epigastric pain, seizures.
Treatment: gastric lavage, prescription of activated charcoal, symptomatic therapy.
Bral is contraindicated in pregnant women, nursing mothers and children in the first three months of life.
Spasmalin, Maxigan, Spasmalgon, Spazgan, Revalgin
|Conditions of storage|
In a dry, light-protected place at a temperature not exceeding 25 °C.
Micro Labs Ltd, India
Micro Labs Ltd
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