Timolol-MEZ, eye drops 0.5% 5 ml

Antiglaucoma drug β-adrenoblocker.

Nonselective p-adrenoreceptor blocker without sympathomimetic activity.

When used topically, it lowers intraocular pressure by reducing aqueous humor formation and slightly increasing its outflow.

Lowering intraocular pressure does not affect accommodation or pupil size, so there is no deterioration in visual acuity; it does not reduce the quality of night vision.

The effect occurs 20 minutes after injection. The maximum effect is observed in 1-2 hours. The duration of action is 24 hours.

Indications

Elevated intraocular pressure, GlaucomaOpen angle glaucoma, secondary glaucoma (uveal, aphakic, posttraumatic), ocular hypertension, closed angle glaucoma (in combination with myotics).

Active ingredient

Timolol

How to take, the dosage

The duration of treatment depends on the indication, the individual sensitivity of the patient and the doctor’s recommendations.

Interaction

Use with caution concomitantly with hypotensive drugs, other beta-adrenoblockers, insulin or oral hypoglycemic drugs, glucocorticosteroid drugs, psychoactive drugs, and drugs whose action is associated with increased release of epinephrine.

Special Instructions

During the treatment at least once in 6 months the lacrimation function, corneal integrity and visual field size should be monitored, intraocular pressure should be measured at least once a month.

Use with caution in chronic obstructive pulmonary disease, cardiac insufficiency, retinal detachment, thyrotoxicosis, myasthenia gravis, sinoatrial blockade, peripheral blood circulation disorders (including Raynaud’s syndrome), pheochromocytoma.

Do not use soft contact lenses during the treatment. Hard contact lenses should be taken off before the injection and put on not earlier than 15 min afterwards.

Two p-adrenoblockers should not be injected into the eyes simultaneously.

Long-term use of timolol may lead to weakening of the effect.

If patients are transferred to timolol treatment, correction of refraction may be required after the effects of previously used myotics.

beta-adrenoblockers (including In local use) may increase hypoglycemic effect of antidiabetic agents and mask symptoms of hypoglycemia.

Contraindications

.

Side effects

Local reactions: eyelid skin hyperemia, burning and itching in the eyes, conjunctival hyperemia, lacrimation or reduced lacrimation, photophobia, corneal epithelium edema, short-term visual acuity impairment; blepharitis, conjunctivitis, with long-term use, development of surface pitting keratopathy (decrease in corneal transparency) and corneal sensitivity decrease, keratitis, possible ptosis, diplopia.

Overdose

No symptoms of overdose have been reported when used topically at the recommended dose.

Pregnancy use

In pregnancy, the drug is used if the expected benefit to the mother exceeds the potential risk to the fetus or child.

Similarities

Arutimol, Okupres-E, Okumed, Timolol-Akos, Timolol Renewal, Timolol-SOLofarm