Tamoxifen, tablets 20 mg 30 pcs

Cancer, Breast Cancer

• Breast cancer in menopausal women;
• breast cancer in men after castration;
• kidney cancer;
• melanoma (containing estrogen receptors);
• ovarian cancer;
• prostate cancer in resistance to other drugs.

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Active ingredient

Tamoxifen

Composition

1 tablet contains:

Active ingredients:

Tamoxifen citrate 30.4 mg, which is equivalent to a tamoxifen content of 20 mg.

Auxiliary Substances:

Corn starch,

Lactose monohydrate,

povidone,

sodium starch glycolate,

magnesium stearate,

purified water.

How to take, the dosage

The dosing regimen is established individually, depending on the indication, the patient’s condition, and the antitumor therapy regimen used.

Interaction

Concomitant use with anticoagulants coumarin derivatives increases the risk of increased anticoagulant effect; with cytostatics – possible increased risk of thrombosis.

In concomitant use with allopurinol hepatotoxic effect is possible; with aminoglutethimide – decrease of plasma concentration of tamoxifen, probably due to its increased metabolism.

In patients receiving tamoxifen, atracurium-induced neuromuscular blockade may be prolonged.

The concomitant use of bromocriptine may increase the dopaminergic effect of bromocriptine. In patients receiving tamoxifen, when using warfarin, there is a risk of developing a threatening clinical situation: prolongation of prothrombin time, hematuria, hematoma are possible.

Concomitant use with mitomycin increases the risk of hemolytic-uremic syndrome.

The concentration of tamoxifen in plasma may decrease, which appears to be due to induction of CYP3A4 isoenzyme by rifampicin.

Estrogens may decrease the therapeutic effect of tamoxifen.

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Contraindications

• Trombophlebitis
• Pregnancy
• High sensitivity to tamoxifen.

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Side effects

Digestive system disorders:nausea, vomiting, increased liver transaminase activity; in some cases – fatty liver infiltration, cholestasis, hepatitis.

CNS side: rarely – depression, dizziness, headache, retrobulbar neuritis.

As for the visual organ: rarely – retinopathy, keratopathy, cataracts.

Hematopoietic system disorders: rarely – thrombocytopenia, leukopenia.

Endocrine system disorders:in women – endometrial hyperplasia, vaginal bleeding, hot flashes, weight gain; in men – impotence, decreased libido.

With the cardiovascular system:edema, thromboembolism, phlebitis.

Dermatological reactions:alopecia, rash, itching.

Other:bone and lesion pains, increased body temperature.

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Overdose

Acute overdose with tamoxifen has not been observed in humans.

Symptoms:An overdose should be expected to cause an increase in the adverse reactions described above.

Treatment:There are no specific antidotes, treatment should be symptomatic.

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