Phenylephrine is an alpha 1-adrenoceptor stimulator that slightly affects the beta-adrenoceptors of the heart; it is not a catecholamine because it contains only one hydroxyl group in the aromatic core.
Acute arterial hypotension. – Vascular insufficiency in overdose with vasodilators. – Shock (traumatic, toxic). – As a vasoconstrictor during local anesthesia.
Solution for injection is clear, colorless.
Phenylephrine reduces the antihypertensive effect of diuretics and hypotensive agents, beta-adrenoblockers (risk of arterial hypertension and cardiovascular disorders).
Directions for use
The drug is administered intravenously, subcutaneously or intramuscularly. In case of collapse a single dose by intravenous injection is 0.1-0.5 ml of 1% solution. During intravenous administration single dose is diluted in 20 ml of 5% dextrose (glucose) solution or 0.9% sodium chloride solution and slowly injected by trickle.
During treatment, you should monitor the electrocardiogram, blood pressure, minute blood volume, blood circulation in the extremities and at the injection site.
Hypersensitivity to any of the drug components; diseases accompanied by left ventricular outflow tract obstruction (severe aortic stenosis, hypertrophic cardiomyopathy); pheochromocytoma; arterial hypertension of any severity; ventricular fibrillation; glucose-6-phosphate dehydrogenase deficiency; porphyria; thyrotoxicosis; closed-angle glaucoma; acute myocardial infarction; use concomitantly with monoamine oxidase inhibitors (MAOIs) and within 14 days after stopping MAOI inhibitor therapy; halothane or cyclopropane narcosis; pregnancy and breastfeeding; age under 18 years.
According to the World Health Organization, adverse effects are classified according to their frequency of development as follows:
Symptoms: headache, significant increase in blood pressure, reflex bradycardia, ventricular extrasystole, brief paroxysms of ventricular tachycardia, a feeling of heaviness in the head and extremities.
Adequate and strictly controlled studies on the use of the drug during pregnancy and breastfeeding have not been conducted.
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|Conditions of storage|
At a temperature not higher than 25 ° C.
Grotex Ltd, Russia
solution for injection
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