Rinsasip with vitamin C Blackcurrant, 5 g 10 pcs.

Symptomatic treatment of “colds”, flu, acute respiratory infections (febrile syndrome, pain syndrome, rhinorrhea).

Composition

1 sachet (5 g) contains

The active ingredients:

paracetamol 750 mg,

ascorbic acid 200 mg,

caffeine 30 mg,

pheniramine maleate 20 mg,

phenylephrine hydrochloride 10 mg,

Excipients:

citric acid 200 mg,

sodium saccharinate – 40 mg,

sodium citrate – 500 mg,

sucrose – 2915 mg,

the dye azorubin (E122) – 4 mg,

Fruit flavoring (Tutti Frutti) – 166.7 mg,

Raspberry flavoring – 66.7 mg,

Blackcurrant flavoring – 66.7 mg.

How to take, the dosage

Inside.

Pour the contents of one sachet (sachet) in a glass, pour hot water, stir until completely dissolved and drink (optional sugar or honey can be added).

The drug is recommended to take 1-2 hours after eating.

Adults and children over 15 years: take one sachet 3-4 times a day with intervals between doses of 4-6 hours.

The maximum daily dose is 4 sachets.

The course of treatment without consulting the doctor is not more than 5 days.

Interaction

Increases the effects of monoamine oxidase inhibitors (MAOIs), sedatives, ethanol.

When taken with digoxin or other cardiac glycosides may increase the risk of arrhythmia and myocardial infarction.

Antidepressants, antiparkinsonics, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation.

Glucocorticosteroids increase the risk of glaucoma.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects.

Metoclopramide and domperidone increase and colestyramine reduces the absorption rate of paracetamol. Paracetamol reduces the effectiveness of diuretic and uricosuric drugs.

Simultaneous administration with barbiturates, diphenin, carbamazepine, rifampicin and other inducers of microsomal liver enzymes increases the risk of hepatotoxic effects of paracetamol.

In most patients on long-term warfarin, infrequent use of paracetamol generally has little or no effect on the international normalized ratio (INR). However, with prolonged regular use, paracetamol increases the effect of indirect anticoagulants (warfarin and other coumarin derivatives), which increases the risk of bleeding.

A single large dose of caffeine increases renal excretion of lithium. Abrupt cessation of caffeine intake may lead to increased serum lithium concentrations.

When taken simultaneously with monoamine oxidase inhibitors (MAOIs), furazolidone, pheniramine may lead to hypertensive crisis, agitation, hyperpyrexia.

When taken with MAO inhibitors, phenylephrine may lead to high blood pressure.

Phenylephrine reduces the effectiveness of beta-blockers and antihypertensive drugs.

Also reduces the hypotensive effect of guanethidine, which, in turn, increases the alpha-adrenomimetic activity of phenylephrine.

Tricyclic antidepressants increase the adrenomimetic effect of phenylephrine, simultaneous administration of halothane increases the risk of ventricular arrhythmia.

Special Instructions

During the treatment you should refrain from taking alcohol.

If the symptoms worsen or persist for 5 days, as well as if new symptoms appear, you should consult a doctor.

The drug may cause drowsiness.

The drug contains sucrose, which should be considered by patients suffering from diabetes, as well as those who are on a hypocaloric diet.

One single dose contains from 2915.0 to 3136.0 mg of sucrose, which corresponds to 0.24-0.26 BE.

Keep out of reach of children.

If the drug is swallowed by a child, seek medical assistance immediately.

If the drug has expired or has passed its expiration date – do not throw it in the sewage or on the street! Place the medication in a bag and put it in a trash container. These measures will help protect the environment!

Synopsis

Blackcurrant: pink to pinkish red powder with white and red flecks.

Contraindications

• Developed coronary atherosclerosis, portal hypertension, simultaneous use of tricyclic antidepressants, beta-adrenoblockers, monoamine oxidase inhibitors (MAOIs) and cessation of their use less than 2 weeks ago;
• Sugar/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption;
• High sensitivity to the individual components of the drug, as well as to sympathomimetic drugs;
• Current use of drugs containing the substances in the drug;
• Pregnancy, lactation, children under 15 years of age, alcoholism.

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Side effects

Allergic reactions: skin rash, itching, urticaria, angioedema, hypersensitivity reaction, anaphylactic reaction.

Nervous system: headache, dizziness, insomnia, sleepiness, increased excitability.

Cardiovascular system: increase in blood pressure, tachycardia, palpitations.

Digestive system: nausea, vomiting, pain in the epigastric region, dry mouth, increased liver enzymes activity, hepatotoxic effect.

Senses: mydriasis, accommodation paresis, increased intraocular pressure.

Blood organs: anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia.

Urinary system: nephrotoxicity (renal colic, glucosuria, interstitial nephritis, papillary necrosis), difficulty in urination.

Other: bronchospasm, dry nasal mucosa.

Serious skin reactions:

Very rare:

– Acute generalized exanthematous pustulosis (OGEP). An acute condition with the development of pustular rashes. It is characterized by fever and diffuse erythema accompanied by burning and itching. Edema of the face, hands and mucous membranes may occur;

– Stevens-Johnson syndrome (SJS) (malignant erythema exudative). A severe form of erythema multiforme with blisters on the mucosa of the mouth, throat, eyes, genitals, other areas of the skin and mucous membranes.

– Toxic epidermal necrolysis (TEN, Lyell’s syndrome). The syndrome is a consequence of extensive apoptosis of keratinocytes, which leads to peeling of large areas of skin at the dermoepidermal junction. Affected skin has the appearance of scalded with boiling water.

If you notice one of the above side effects, you should stop taking the drug and immediately contact your doctor!

Overdose

In case of overdose you should immediately consult a doctor.

Prompt medical attention is critical, even if you do not notice any signs or symptoms.

• Ascorbic acid:

Symptoms of acute overdose: diarrhea and other gastrointestinal disorders.

Symptoms of chronic intoxication with ascorbic acid: impaired renal excretory function, formation of kidney stones, decreased capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies, iron metabolism disorders), erosion of tooth enamel.

• Caffeine:

Symptoms of acute overdose: abdominal pain, nausea, vomiting, fever, chills, headache, agitation, insomnia, irritability, loss of appetite, weakness, tremor, anxiety, state of altered consciousness, delirium, hallucinations, increased blood pressure followed by hypotension, tachycardia, tachypnoea, hypokalemia, hyponatremia, hyperglycemia, metabolic acidosis, epileptic seizures, seizures, myoclonias and rhabdomyolysis, supraventricular and ventricular arrhythmias.

Symptoms of chronic caffeine intoxication, (“caffeinism”): irritability, insomnia, anxiety, emotional lability, chronic abdominal pain.

• Pheniramine:

Symptoms: CNS depression, hyperthermia, anticholinergic syndrome (mydriasis, facial flushes, fever, dry mouth, urinary retention, bowel paresis), tachycardia, hypotension, hypertension, nausea, vomiting, psychomotor agitation, disorientation, hallucinations, psychosis, seizures, arrhythmias.

Rarely, rhabdomyolysis and renal failure develop in patients with agitation, seizures, or patients in coma.

• Phenylephrine:

Symptoms: headache, nausea, vomiting, irritability, agitation, insomnia, psychosis, seizures, palpitations, tachycardia, increased blood pressure, reflex bradycardia.

• Paracetamol:

Symptoms manifested after taking more than 7.5-10 g: Within the first 24 h after ingestion – pallor of the skin, nausea, vomiting, anorexia, abdominal pain, increased prothrombin time, impaired glucose metabolism, hypokalemia, metabolic acidosis (incl.

Symptoms of liver function abnormalities may appear 12-48 hours after overdose: increase of liver transaminases activity, hepatonecrosis. In severe cases – hepatic failure with progressive encephalopathy, coma. Rarely, liver failure develops fulminantly and may be complicated by renal failure (tubular necrosis).

The threshold of overdose may be lowered in elderly patients and children, in patients taking certain drugs (eg, inducers of microsomal liver enzymes), alcohol or suffering from exhaustion.

Treatment: gastric lavage, administration of activated charcoal during the first 6 hours after overdose, administration of SH-group donators and glutathione synthesis precursors – methionine 8-9 hours after overdose and acetylcysteine 12 hours after it. The need for additional therapeutic measures (further administration of methionine and acetylcysteine) depends on the concentration of paracetamol in blood, as well as on the time elapsed after its administration. Symptomatic therapy.

Pregnancy use

Due to the lack of clinical data, the safety of using the drug during pregnancy and breastfeeding has not been established, so the drug is contraindicated for this category of patients.