Lincomycin, capsules 250 mg 20 pcs

The antibiotic produced by Streptomyces lincolniensis has a bacteriostatic effect.

Sensitive in vivo: Staphylococcus aureus (penicillinase-producing and nonproducing strains), Streptococcus pneumoniae.

Sensitive in vitro: Aerobic Gram-positive cocci – Streptococcus pyogenes, Streptococcus spp. group viridans. Aerobic gram-positive bacilli – Corynebacterium diphtheriae. Anaerobic gram-positive spore-forming bacilli – Propionibacterium acnes. Anaerobic gram-positive spore-forming bacilli – Clostridium tetani, Clostridium perfringens.

Ineffective against most strains of Enterococcus faecalis; not effective against Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae and other gram-negative bacteria; fungi and viruses. Optimal action is in alkaline environment (pH 8-8.5).

Lincomycin resistance develops slowly. In high doses it has a bactericidal effect.

Indications

Bacterial infections caused by susceptible microorganisms (primarily Staphylococcus aureus and Streptococcus spp., especially microorganisms resistant to penicillins, as well as in cases of allergy to penicillins):

subacute septic endocarditis,
lung abscess,
pleural empyema,
pleurisy,
otitis,
osteomyelitis (acute and chronic),
purulent arthritis,
postoperative purulent complications,
wound infection,
infections of the skin and soft tissues (pyoderma, furunculosis, phlegmon, erysipelas).

Pharmacological effect

The antibiotic produced by Streptomyces lincolniensis has a bacteriostatic effect.

Sensitive in vivo: Staphylococcus aureus (penicillinase-producing and non-producing strains), Streptococcus pneumoniae.

Sensitive in vitro: Aerobic gram-positive cocci – Streptococcus pyogenes, Streptococcus spp. viridans group. Aerobic gram-positive rods – Corynebacterium diphtheriae. Anaerobic gram-positive non-spore-forming rods – Propionibacterium acnes. Anaerobic gram-positive spore-forming rods – Clostridium tetani, Clostridium perfringens.

Ineffective against most strains of Enterococcus faecalis; does not affect Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae and other gram-negative bacteria; fungi and viruses. The optimum action is in an alkaline environment (pH 8-8.5).

Resistance to lincomycin develops slowly. In high doses it has a bactericidal effect.

Special instructions

If signs of pseudomembranous enterocolitis appear (diarrhea, leukocytosis, fever, abdominal pain, discharge of blood and mucus with feces), in mild cases it is sufficient to discontinue the drug and prescribe ion exchange resins (colestyramine), in severe cases, replacement of the loss of fluid, electrolytes and protein is indicated, vancomycin – orally, in a daily dose of 0.5-2 g (in 3-4 doses) for 10 days or bacitracin.

Active ingredient

Lincomycin

Composition

Each capsule contains 250 mg lincomycin

Contraindications

Hypersensitivity,
pregnancy (except for cases when it is necessary for “vital” reasons),
lactation period,
severe liver and/or kidney failure;
children’s age (up to 12 years for this dosage form).

Recommendations for use

Inside, 1-2 hours before meals.

Adults and children over 12 years old – 500 mg 3-4 times a day. The duration of treatment, depending on the form and severity of the disease, is 7-14 days (for osteomyelitis – 3 weeks or more).

For long-term or repeated courses, treatment should be carried out under monitoring of liver and kidney function.

Manufacturer

Biokhimik JSC, Russia