The enantiomer of cetirizine; a competitive histamine antagonist; blocks H1-histamine receptors, affinity to which is 2 times higher than that of cetirizine.
It influences the histamine-dependent stage of allergic reactions; it reduces migration of eosinophils, decreases vascular permeability, limits the release of inflammatory mediators.
It prevents and facilitates allergic reactions, has antiexudative, antipruritic action; it has practically no anticholinergic and antiserotonic action. In therapeutic doses it practically has no sedative effect.
The action begins 12 minutes after a single dose in 50% of patients, within 1 hour in 95% of patients and lasts for 24 hours.
Indications
Dermatosis, Neurodermitis, Pollinosis, Urticaria, Sneezing, Allergic conjunctivitis, Runny nose (rhinitis), Allergy, Skin itching, Increased lacrimation, Allergic rhinitis
Symptomatic treatment of year-round and seasonal allergic rhinitis and conjunctivitis (itching, sneezing, rhinorrhea, lacrimation, conjunctival hyperemia); hay fever (pollinosis); urticaria, includingincluding chronic idiopathic urticaria; Quincke’s edema; allergic dermatoses accompanied by itching and rashes.
Active ingredient
Levocetirizine
Composition
1 tablet contains:
The active ingredient:
Levocetirizine 5 mg
How to take, the dosage
Overly, with meals or on an empty stomach with a small amount of water, without chewing.
The recommended dose is 5 mg (1 tablet) for adults and children over 6 years old, elderly patients (provided that kidney function is normal).
The course of treatment in case of polinosis is 1-6 weeks; in chronic diseases (year-round rhinitis, atopic dermatitis) – up to 18 months.
Interaction
Theophylline (400 mg/day) decreases total clearance of levocetirizine by 16%, while the kinetics of theophylline is not changed.
Co-administration with macrolides or ketoconazole did not cause significant changes in ECG.
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Special Instructions
During treatment, it is necessary to refrain from potentially hazardous activities that require high concentration and rapid psychomotor reactions, as well as from drinking ethanol.
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Contraindications
Hypersensitivity (including to piperazine derivatives), severe CKD (IQ less than 10 ml/min), pregnancy, lactation, children (under 6 years).
With caution. CKD, advanced age (decreased glomerular filtration is possible).
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Side effects
Headache, drowsiness, dry mouth, fatigue, rarely – migraine, dizziness, dyspepsia, allergic reactions (angioedema, rash, urticaria, skin itching).
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Overdose
Symptoms: drowsiness, in children – anxiety, irritability.
Treatment: gastric lavage, activated charcoal, symptomatic therapy. There is no specific antidote. Hemodialysis is not effective.
Similarities
Xizal, Suprastinex, Glencet, Elcet, Levocetirizine tablets, Allerwei, Levocetirizine
Weight | 0.010 kg |
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Manufacturer | Israel |
Medication form | pills |
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