Levocetirizine is the active substance of the drug Levocetirizine-Teva is the R-enantiomer of cetirizine, which belongs to the group of competitive histamine antagonists and blocks H1-histamine receptors.
Levocetirizine influences the histamine-dependent stage of allergic reactions and also reduces migration of eosinophils, decreases vascular permeability and limits release of inflammatory mediators.
Levocetirizine prevents development and facilitates allergic reactions, has antiexudative and antipruritic action and practically has no anticholinergic and antiserotonic action.
In therapeutic doses it has practically no sedative effect.
Allergic conjunctivitis, Sneezing, Dermatosis, Runny nose (rhinitis), Pollinosis, Allergy, Neurodermatitis, Allergic rhinitis, Urticaria, Skin itching, Increased lacrimation – Treatment of symptoms of year-round (persistent) and seasonal (intermittent) allergic rhinitis and allergic conjunctivitis, such as itching, sneezing, nasal congestion, rhinorrhea, lacrimation, conjunctival hyperemia; Pollinosis (hay fever).
– Other allergic dermatoses associated with itching and rashes.
– in chronic renal insufficiency (correction of the dosing regimen is necessary);
– in elderly patients (with age-related decrease in glomerular filtration);
– In patients with spinal cord injury, prostatic hyperplasia and in presence of other predisposing factors to urinary retention as levocetirizine may increase the risk of urinary retention.
– with alcohol (see “Interaction with other medicinal products”);
– when prescribed to pregnant women and during breastfeeding.
How to take, the dosage
Film-coated tablets are taken orally, swallowed whole during meals or on an empty stomach with a small amount of water.
Adults and children over 6 years: The daily dose is 5 mg (1 tablet) once.
Theophylline (400 mg/day) decreases total clearance of levocetirizine by 16%, while the kinetics of theophylline is not changed.
Co-administration with macrolides or ketoconazole did not cause significant changes in ECG.
During treatment, it is necessary to refrain from potentially hazardous activities that require high concentration and rapid psychomotor reactions, as well as from drinking ethanol.
Hypersensitivity (including to piperazine derivatives), severe CKD (IQ less than 10 ml/min), pregnancy, lactation, children (under 6 years).
With caution. CKD, advanced age (decreased glomerular filtration is possible).
Headache, drowsiness, dry mouth, fatigue, rarely – migraine, dizziness, dyspepsia, allergic reactions (angioedema, rash, urticaria, skin itching).
Symptoms: drowsiness, in children – anxiety, irritability.
Treatment: gastric lavage, activated charcoal, symptomatic therapy. There is no specific antidote. Hemodialysis is not effective.
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