Leflobakt, 250 mg 10 pcs

Leflobakt^® is a synthetic broad-spectrum antimicrobial bactericidal drug from the group of fluoroquinolones.

Levofloxacin is the left-handed isomer ofloxacin. Levofloxacin blocks enzymes of DNA-enzyme (topoisomerase II) and topoisomerase IV, breaks superspiralization and cross-linking of DNA breaks, causes deep morphological changes in cytoplasm, cell wall and bacterial membrane.

Levofloxacin is active against most strains of microorganisms under both in vitro and in vivo conditions.

Gram-positive aerobic microorganisms: Staphylococcus spp. (coagulazonegative, methicillin-sensitive / moderately methicillin-sensitive strains), Staphylococcus aureus (methicillin-sensitive strains), Staphylococcus epidermidis (methicillin-sensitive strains), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae (penicillin-sensitive/ moderately penicillin-sensitive/penicillin-resistant strains), Streptococcus spp (groups C, G), Streptococcus viridans (penicillin-sensitive and penicillin-resistant strains), Enterococcus faecalis, Corynebacterium diphtheriae, Listeria monocytogenes.

Gram-negative aerobic microorganisms: Acinetobacter spp. (including Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus), Actinobacillus actinomycetemcomitans, Citrobacter freundii, Citrobacter diversus, Eikenella corrodens, Enterobacter spp. Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, Enterobacter sakazakii), Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae (ampicillin-sensitive/ampicillin-resistant strains), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. (including Klebsiella oxytoca, Klebsiella pneumoniae), Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae (including penicillin-producing strains), Neisseria meningitidis, Pasteurella spp. Pasteurella canis, Pasteurella dagmatis, Pasteurella multocida), Proteus mirabilis, Proteus vulgaris, Providencia spp. (including Providencia rettgeri, Providencia stuartii), Pseudomonas spp. (including Pseudomonas aeruginosa, Pseudomonas fluorescens), Salmonella spp, Serratia spp. (including Serratia marcescens).

Anaerobic microorganisms: Bacteroides fragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterium spp., Veillonella spp.

Other microorganisms: Bartonella spp, Chlamydia (Chlamydophila) pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella spp. (including Legionella pneumophila), Mycobacterium spp. (including Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to levofloxacin:
– lower respiratory tract (including chronic bronchitis, pneumonia);
— ENT organs (including sinusitis, otitis media);
— genitourinary organs (including acute pyelonephritis, prostatitis, urogenital chlamydia);
– skin and soft tissues (including suppurating atheromas, abscess, boils);
As part of complex therapy of drug-resistant forms of tuberculosis.

Pharmacological effect

Leflobact® is a synthetic broad-spectrum antimicrobial bactericidal drug from the group of fluoroquinolones.

Levofloxacin is a levorotatory isomer of ofloxacin. Levofloxacin blocks the enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and cross-linking of DNA breaks, and causes profound morphological changes in the cytoplasm, cell wall and membrane of bacteria.

Levofloxacin is active against most strains of microorganisms both in vitro and in vivo.

Gram-positive aerobic microorganisms: Staphylococcus spp. (coagulase-negative, methicillin-sensitive/moderately methicillin-sensitive strains), Staphylococcus aureus (methicillin-sensitive strains), Staphylococcus epidermidis (methicillin-sensitive strains), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae (penicillin-sensitive/moderately penicillin-sensitive/penicillin-resistant strains), Streptococcus spp (groups C, G), Streptococcus viridans (penicillin-sensitive and penicillin-resistant strains), Enterococcus faecalis, Corynebacterium diphtheriae, Listeria monocytogenes.

Gram-negative aerobic microorganisms: Acinetobacter spp. (including Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus), Actinobacillus actinomycetemcomitans, Citrobacter freundii, Citrobacter diversus, Eikenella corrodens, Enterobacter spp. (including Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, Enterobacter sakazakii), Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae (ampicillin-sensitive/ampicillin-resistant strains), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. (including Klebsiella oxytoca, Klebsiella pneumoniae), Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae (including penicillinase-producing strains), Neisseria meningitidis, Pasteurella spp. (including Pasteurella canis, Pasteurella dagmatis, Pasteurella multocida), Proteus mirabilis, Proteus vulgaris, Providencia spp. (including Providencia rettgeri, Providencia stuartii), Pseudomonas spp. (including Pseudomonas aeruginosa, Pseudomonas fluorescens), Salmonella spp., Serratia spp. (including Serratia marcescens).

Anaerobic microorganisms: Bacteroides fragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterium spp., Veillonella spp.

Other microorganisms: Bartonella spp., Chlamydia (Chlamydophila) pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella spp. (including Legionella pneumophila), Mycobacterium spp. (including Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum.

Active ingredient

Levofloxacin

Composition

1 tablet contains levofloxacin (in the form of hemihydrate) 250 mg.

Excipients:

calcium stearate,

starch 1500,

potato starch,

crospovidone (kollidon CL-M),

povidone,

lactose,

talc,

microcrystalline cellulose.

Shell composition:

hypromellose, macrogol, titanium dioxide, tropeolin 0.

Contraindications

— epilepsy;
– tendon damage due to previous treatment with quinolones;
– impaired renal function in CC – pregnancy;
– lactation period;
– children and adolescents up to 18 years of age;
– hypersensitivity to the components of Leflobact.
The drug should be used with caution in cases of glucose-6-phosphate dehydrogenase deficiency and in elderly patients (there is a high probability of concomitant decline in renal function).

Side Effects

From the digestive system: nausea, vomiting, diarrhea (including blood), indigestion, loss of appetite, abdominal pain, pseudomembranous enterocolitis, increased activity of liver transaminases, hyperbilirubinemia, hepatitis, dysbacteriosis.

From the cardiovascular system: decreased blood pressure, vascular collapse, tachycardia, prolongation of the QT interval.

Metabolism: hypoglycemia (including increased appetite, increased sweating, trembling).

From the central nervous system and peripheral nervous system: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, fear, hallucinations, confusion, depression, movement disorders, epileptic seizures (in predisposed patients).

From the senses: disturbances of vision, hearing, smell, taste and tactile sensitivity.

From the musculoskeletal system: arthralgia, muscle weakness, myalgia, tendon rupture, tendinitis, rhabdomyolysis.

From the urinary system: hypercreatininemia, interstitial nephritis, acute renal failure.

From the hematopoietic system: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhages.

Allergic reactions: itching and redness of the skin, swelling of the skin and mucous membranes, urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), bronchospasm, suffocation, anaphylactic shock, allergic pneumonitis, vasculitis.

Other: asthenia, exacerbation of porphyria, photosensitivity, persistent fever, development of superinfection.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Manufacturer

Sintez, Russia