Ibuklin, 400 mg+325 mg 10 pcs

Contraindications

• Excessive individual sensitivity to the components of the drug (including other NSAIDs).
• Gastrointestinal erosive diseases (including gastric and duodenal ulcers, Crohn’s disease, ulcerative colitis) or ulcer bleeding in the active phase or in the history (two or more confirmed episodes of peptic ulcer disease or ulcer bleeding).
• Cerebrovascular or other bleeding.
• Hemophilia or other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis, intracranial hemorrhage.
• Severe renal insufficiency (creatinine clearance (CK) less than 30 ml/min).
• Complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and sinuses, and intolerance of acetylsalicylic acid or other NSAIDs (including history).
• Severe heart failure (NYHA class IV).
• Decompensated heart failure.
• Optic nerve damage.
• Genetic absence of glucose-6-phosphate dehydrogenase.
• Diseases of the blood system.
• Period after coronary artery bypass surgery.
• Progressive renal disease.
• Severe hepatic failure or active liver disease.
• Confirmed hyperkalemia.
• Pregnancy (third trimester).
• Childhood under 18 years of age.

With caution:

• Ischemic heart disease, chronic heart failure, peripheral artery disease, arterial hypertension, blood diseases of unclear etiology (leukopenia and anemia), cerebrovascular disease, dislipidemia / hyperlipidemia.
• Anamnesis of a single episode of gastric or duodenal ulcer or gastrointestinal bleeding, Helicobacter pylori infection, gastritis, enteritis, colitis, ulcerative colitis in the anamnesis.
• Viral hepatitis, mild to moderate hepatic insufficiency, benign hyperbilirubinemia (Gilbert, Dubin-Johnson, and Rotor syndrome), cirrhosis with portal hypertension.
• Renal failure, including dehydration (CK less than 30-60 ml/min), nephrotic syndrome.
• Bronchial asthma or allergic diseases in acute stage or in anamnesis – possible development of bronchospasm.
• Systemic lupus erythematosus or mixed connective tissue disease (Sharp syndrome) – increased risk of aseptic meningitis.
• Chickenpox, severe somatic diseases, diabetes.
• . Concomitant use of other NSAIDs, oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline).
• Elderly age, smoking, alcoholism.
• Pregnancy I-II trimester, breastfeeding period.

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Side effects

Gastrointestinal disorders

Overdose

Symptoms: gastrointestinal disorders (diarrhea, nausea, vomiting, anorexia, epigastric pain), increased PV, bleeding after 12-48 hours, lethargy, drowsiness, depression, headache, tinnitus, impaired consciousness, heart rhythm disturbances, BP decrease, hepato- and nephrotoxicity symptoms, seizures, possible hepatonecrosis development.

If overdose is suspected, seek medical attention immediately.

Treatment: gastric lavage during the first 4 hours; alkaline drinking, forced diuresis; administration of activated charcoal, administration of SH-group donators and precursor of glutathione synthesis – methionine – 8-9 hours after overdose and N-acetylcysteine orally or v/v 12 hours later, antacids; hemodialysis; symptomatic therapy. The need for additional therapeutic measures (further methionine administration, intravenous N-acetylcysteine) is determined depending on the concentration of paracetamol in blood, as well as on the time elapsed after its administration.

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Pregnancy use

In I and II trimester of pregnancy the use of the drug Ibuklin® is possible only by prescription in cases when the potential benefit exceeds the possible risk to the mother and the potential risk to the fetus. Administration of the drug in the III trimester of pregnancy is contraindicated.