Glucose-Solofarm Polyflac Domus, 5% 200 ml

How to take, the dosage

Intravenous drip.

The 5% solution is administered at a maximum rate of up to 7 ml (150 drops)/min (400 ml/h); the maximum daily dose for adults is 2 L.

Intravenously with a stream.

10-50 ml of 5% and 10% solutions.

In adults with normal metabolism the daily dose of administered glucose should not exceed 4-6 g/kg, i.e. about 250-450 g (when the metabolic rate decreases, the daily dose is reduced to 200-300 g), while the volume of the administered liquid is 30-40 ml/kg.

In children for parenteral nutrition the first day 6 g of glucose/kg/day, later on – up to 15 g/kg/day, along with glucose if necessary fats and amino acids are administered.

When calculating the dose of glucose when administering 5% and 10% solutions, the following should be taken into account: for children with a weight of 2-10 kg – 100-165 ml/kg/day, for children with a weight of 10-40 kg – 45-100 ml/kg/day.

In normal state of metabolism the maximum rate of glucose administration in adults is 0.25-0.5 g/kg/h. (when the intensity of metabolism decreases, the rate of administration is reduced to 0.125-0.25 g/kg/h). Children should have solutions with maximum concentration of 20-25%; glucose rate of administration should not exceed 0.75 g/kg/h.

Interaction

When combining with other drugs it is necessary to control pharmaceutical compatibility, including visually.

Special Instructions

Control of water-electrolyte equilibrium.

The 5% solution can be combined with isotonic sodium chloride solution to increase osmolarity.

For more complete and rapid absorption of glucose administered in large doses, 4-5 units of short-acting insulin may be administered simultaneously with it, at the rate of 1 IU of insulin per 4-5 g of glucose.

Patients with diabetes are administered glucose under control of its content in the blood and urine.

Impact on the ability to drive and operate machinery

No adverse effect on the ability to drive vehicles and operate machinery has been found.

Contraindications

• hyperglycemia;
• hyperlactacidemia;
• hyperhydration;
• postoperative disorders of glucose utilization;
• circulatory disorders that threaten cerebral and pulmonary edema;
• cerebral edema;
• pulmonary edema;
• acute left ventricular failure;
• hyperosmolar coma;
• childhood (for solutions over 20-25%);
• hypersensitivity.

With caution: decompensated chronic heart failure, chronic renal failure (oligo-, anuria), hyponatremia, diabetes.

Side effects

Hypervolemia, acute left ventricular failure; if the rate of administration is exceeded – osmotic diuresis with loss of water, electrolytes and development of hyperosmolar coma.

Overdose

Symptoms: hyperglycemia, glucosuria, hyperglycemic, hyperosmolar coma, hyperhydration, disruption of water-electrolyte balance, increased liponeogenesis with increased production of CO₂, leading to a sharp increase in minute respiratory volume and, consequently, respiratory rate, fatty liver infiltration.

Treatment: discontinue glucose administration, administer short-acting insulin, symptomatic therapy.

Similarities

Dextrose, Glucose Solution, Glucose