Ketoprofen belongs to the group of NSAIDs with anti-inflammatory, anti-exudative and analgesic effect.
In the form of gel provides local treatment of joints, tendons, ligaments, muscles, skin, veins, lymph vessels and lymph nodes. In joint syndrome it relieves pain in the joints at rest and when moving, reduces morning stiffness and joint swelling.
It penetrates well through the skin. Bioavailability of the gel is about 5%. The absorbed part of ketoprofen binds with blood plasma proteins by about 99%. It is metabolized in the liver. About 80% of the dose taken is excreted in the urine as metabolites, less than 10% – unchanged.
It does not cumulate in the body.
Osteochondrosis, Neck pain, Osteoarthritis, Sprains and strains, Arthrosis and arthritis, Pain after injuries and operations, Myositis, Lumbago, Sciatica, Back pain, Swelling after injuries and operations, Inflamed tendons, Bursitis, Rheumatoid arthritis, Gout, Myalgia (muscle pain), Bruises, Radiculitis, Pain in joints (arthralgia)
As a drug for external use in symptomatic treatment:
- back pain;
- inflammatory-degenerative diseases of the musculoskeletal system ( including.
- inflammatory and degenerative diseases of the musculoskeletal system (including arthritis, bursitis, synovitis, tendinitis, lumbago);
- uncomplicated injuries (including.
- in combination therapy for inflammatory diseases of the veins (phlebitis, periphlebitis), lymph vessels, lymph nodes (lymphangitis, superficial lymphadenitis).
Ketoprofen lysine salt, 2.5 g/100.0 g gel
macrogol 200 – 5 g,
methyl parahydroxybenzoate – 0.15 g,
propyl parahydroxybenzoate – 0.05 g,
carbomer – 1.5 g,
trolamine – 2.5 g,
purified water – up to 100 g.
How to take, the dosage
The product is for external use.
A small amount (3-5 cm long strip) of the gel should be applied 2-3 times a day to the appropriate area of the skin and rubbed in gently.
There is no need for a dry dressing as the gel is easily absorbed through the skin, is odorless, colorless, leaves no greasy spots and does not stain clothing.
In frequent and prolonged use symptoms of interaction with other drugs may appear (the same as in systemic use).
In co-administration with other NSAIDs, GCS, ethanol, corticotropin, ulceration and gastrointestinal bleeding may occur.
Concomitant use with oral anticoagulants, heparin, thrombolytics, antiaggregants, cefoperazone, cefamandole increases the risk of bleeding.
Ketoprofen reduces the effect of hypotensive drugs and diuretics (inhibition of prostaglandin synthesis).
It increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose adjustment is necessary). Co-administration with sodium valproate causes impairment of platelet aggregation. Increases the plasma concentration of verapamil and nifedipine.
The gel should not come into contact with the mucous membranes and eyes.
The product should not be applied to damaged skin.
Caution should be exercised with long-term use in patients with severe hepatic or renal impairment.
If a rash occurs, discontinue use and treat accordingly.
- soaking dermatoses, eczema;
- infected abrasions, wounds, burns;
- III trimester of pregnancy;
- period of lactation (breastfeeding);
- Hypersensitivity to ketoprofen and/or other components of the drug;
- high sensitivity to other NSAIDs (ketoprofen may cause bronchospasm in persons sensitive to acetylsalicylic acid and other NSAIDs).
Possible: allergic reactions, skin hyperemia, photosensitization, skin exanthema, purpura.
Because of the low systemic absorption, an overdose of Febrofid is unlikely.
In the I and II trimesters of pregnancy the drug can be used only if necessary.
In the III trimester of pregnancy the drug is contraindicated.
It is not recommended to use during breastfeeding.
Ketonal, OKI, Bystromgel, Flamax Forte, Ketoprofen, Flamax, Fastum, Arquetal Rompharm, Pentalgin Extra-Gel, Ketonal DUO, Ketoprovel, OKI ACT, Brustel
|Conditions of storage|
In a light-protected place at 15-25 °C
Medana Pharma, Poland
gel for external use
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