Exifin, tablets 250 mg 16 pcs

Note: Unlike Exifin® for topical use, oral Exifin® is not effective for variegated shingles.

Active ingredient

Terbinafine

How to take, the dosage

The duration of treatment depends on the indication and the severity of the disease.

Interaction

The clearance of drugs metabolized with cytochrome P450 (e.g., cyclosporine, terfenadine, tolbutamide, triazolam, oral contraceptives) is practically unaffected.

. Inhibits CYP2D6 isoenzyme and interferes with the metabolism of drugs such as tricyclic antidepressants and selective serotonin takeover blockers (e.g., desipramine, fluvoxamine), Beta-adrenoblockers (metoprolol, propranolol), antiarrhythmic drugs (flecainide, propafenone), MAO-B inhibitors (e.g. selegiline) and antipsychotics (e.g. chlorpromazine, haloperidol).

CYP450 enzyme-inducing drugs (e.g., rifampicin) may accelerate excretion of terbinafine.

The CYP450 inhibitor drugs (e.g. cimetidine) may slow down the metabolism and excretion of terbinafine.

The dose of terbinafine may need to be adjusted if these drugs are used concomitantly.

The menstrual cycle may be disrupted if terbinafine and oral contraceptives are used at the same time.

Limits caffeine clearance by 21% and prolongs its half-life by 31%.

It does not affect the clearance of antipyrine, digoxin, warfarin.

Ethanol and other hepatotoxic agents increase the risk of hepatotoxic effects.

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Special Instructions

Before using Exifin® tablets, liver function should be tested.

Contraindications

Hypersensitivity to terbinafine or any other component of the drug.