Diclofenac, 1% ointment 30 g

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It has anti-inflammatory, analgesic and antipyretic effects.

Inhibits COX enzyme in the cascade of arachidonic acid metabolism and disrupts prostaglandin biosynthesis.

When used externally it has anti-inflammatory and analgesic effects. It reduces and relieves pain at the site of application of the ointment (including joint pain at rest and during movement), reduces morning stiffness and joint swelling. Helps to increase the volume of movement.

Indications

Inflammation of tendons, Bursitis, Pain, Neuralgia, Lumbago, Periarthritis, Gout, Neck pain, Sciatica, Back pain, Arthrosis, Rheumatoid arthritis, Joint pain (arthralgia), Pain after injuries and operations, Swelling after injuries and operations, Myalgia (muscle pain), Arthritis, Osteoarthritis

• Rheumatism of the soft tissue

.Inflammatory and degenerative joint diseases (osteochondrosis, osteoarthritis, periarthropathy);

• soft tissue rheumatism;
• traumatic bruises;
• stretches of ligaments, muscles and tendons;
• inflammatory soft tissue edema;
• arthralgia and myalgia caused by heavy physical activity.

.

Active ingredient

Diclofenac

Composition

Active ingredient:

diclofenac sodium 10 mg;

Supplements:

Polyethylene oxide-400,

Polyethylene oxide-4000,
<

1,2-propylene glycol,

nipagin,

nipazole

How to take, the dosage

In a dose of 2-4 g, apply a thin layer to the skin over the inflammation and gently rub it in, the frequency of use is 2-3 times a day.

The maximum daily dose of ointment should not exceed 8 g.

The course of treatment is not more than 14 days. The need for longer use of the drug is determined by the doctor.

Interaction

In concomitant use of the drug Diclofenac with digoxin, phenytoin or lithium drugs may increase plasma concentrations of these drugs; with diuretics and hypotensive agents – possible decrease in the effect of these drugs; with potassium-saving diuretics – possible development of hyperkalemia; with acetylsalicylic acid – decrease of diclofenac concentration in blood plasma and increased risk of side effects.

Diclofenac may increase the toxic effects of cyclosporine on the kidneys.

Diclofenac may cause hypo- or hyperglycemia, therefore concomitant use with hypoglycemic agents requires control of blood glucose concentration.

When using methotrexate for 24 hours before or after taking Diclofenac it is possible that methotrexate concentration may increase and its toxic effect may be increased.

When concomitant use with anticoagulants regular monitoring of blood clotting is required.

Contraindications

• pathological changes in the blood picture of unclear genesis;
• gastric and duodenal ulcer;
• destructive-inflammatory bowel disease in the acute phase;
• pregnancy;
• lactation period (breastfeeding should be avoided);
• children and adolescents under 12 years of age (intravenous, sup.
• children under 6 years of age (tablets, ointment);
• high sensitivity to acetylsalicylic acid or other NSAIDs (including “
• high sensitivity to diclofenac and other components of the drug
• inflammation of the rectum – proctitis (suppositories)

.

Side effects

Skin rash, burning, redness are possible in the place of application of the ointment.

Long-term external use of the drug may cause systemic adverse effects on the digestive system, central nervous system, respiratory system and allergic reactions.

.

Similarities

Diclac, Diclofenac-Teva, Diclo-F, Orthofen, Diclovit, Voltaren, Voltaren Emulsgel, Diclofenac, Voltaren Patch, Dicloran Plus, Orthofen, Diclofenac-Altfarm, Diclofenac-SOLofarm, Dialrapid