Diclofenac, 1% ointment 30 g

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It has anti-inflammatory, analgesic and antipyretic effects.

Inhibits COX enzyme in the cascade of arachidonic acid metabolism and disrupts prostaglandin biosynthesis.

When used externally it has anti-inflammatory and analgesic effects. It reduces and relieves pain at the site of application of the ointment (including joint pain at rest and during movement), reduces morning stiffness and joint swelling. Helps to increase the volume of movement.

Indications

Active ingredient

Composition

Active ingredient:

diclofenac sodium 10 mg;

Supplements:

Polyethylene oxide-400,

Polyethylene oxide-4000,

How to take, the dosage

In a dose of 2-4 g, apply a thin layer to the skin over the inflammation and gently rub it in, the frequency of use is 2-3 times a day.

The maximum daily dose of ointment should not exceed 8 g.

The course of treatment is not more than 14 days. The need for longer use of the drug is determined by the doctor.

Interaction

In concomitant use of the drug Diclofenac with digoxin, phenytoin or lithium drugs may increase plasma concentrations of these drugs; with diuretics and hypotensive agents – possible decrease in the effect of these drugs; with potassium-saving diuretics – possible development of hyperkalemia; with acetylsalicylic acid – decrease of diclofenac concentration in blood plasma and increased risk of side effects.

Diclofenac may increase the toxic effects of cyclosporine on the kidneys.

Diclofenac may cause hypo- or hyperglycemia, therefore concomitant use with hypoglycemic agents requires control of blood glucose concentration.

When using methotrexate for 24 hours before or after taking Diclofenac it is possible that methotrexate concentration may increase and its toxic effect may be increased.

When concomitant use with anticoagulants regular monitoring of blood clotting is required.

Contraindications

Side effects

Skin rash, burning, redness are possible in the place of application of the ointment.

Long-term external use of the drug may cause systemic adverse effects on the digestive system, central nervous system, respiratory system and allergic reactions.

Similarities