Clotrimazole, cream 1% 20 g
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Clotrimazole is a broad-spectrum antifungal agent for local use. Antimycotic effect of the active substance (imidazole derivative) is associated with disruption of ergosterol synthesis, which is a part of the cell membrane of fungi, which changes membrane permeability and causes subsequent cell lysis.
In low concentrations it is fungistatic and in high concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in hydrogen peroxide concentration to toxic levels, which also helps destroy fungal cells.
It is effective against dermatophytes, yeast-like and mold fungi as well as against Pityriasis versicolor (Malazessia furfur) and erythrazma pathogen. It has antimicrobial action against Gram-positive (staphylococci, streptococci) and Gram-negative bacteria (Bacteroides, Gardiierella vaginalis) and against Trichomonas vaginalis.
Clotrimazole is poorly absorbed through the skin and mucous membranes and has almost no systemic action. The concentration in the deep layers of the epidermis is higher than the minimum inhibitory concentration for dermatophytes. When applied externally, the concentration of clotrimazole in the epidermis is higher than in the dermis and subcutaneous tissue.
- Fungal skin diseases, mycoses of skin folds, feet;
- Mycoses, erythrazma, superficial caidiasis, caused by dermatophytes, yeasts (including genus Candida), molds and other fungi and pathogens sensitive to clotrimazole;
- Mycoses complicated by secondary pyoderma.
1 g of cream contains:
The active ingredient:
clotrimazole 10 mg;
How to take, the dosage
The cream is applied in a thin layer 2-3 times a day to previously cleansed (using soap with a neutral pH) and dry affected skin and rubbed gently.
The duration of treatment depends on the severity of the disease, localization of pathological changes and the effectiveness of therapy.
The treatment of dermatomycosis is carried out at least for 4 weeks, pityriasis -1-3 weeks.
In case of fungal diseases of foot ruts, it is recommended to continue therapy for at least 2 more weeks after the elimination of symptoms of the disease.
Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole when used simultaneously.
In the use of the cream, negative interactions with other agents are not known and should not be expected, because the resorption capacity of clotrimazole is very low.
Application of the drug to the skin in the eye area is not recommended. In patients with hepatic insufficiency liver function should be periodically monitored.
In case of signs of hypersensitivity or irritation, treatment should be discontinued.
If there is no effect within 4 weeks, the diagnosis should be confirmed.
Hypersensitivity to clotrimazole or excipients, in the first trimester of pregnancy.
With caution – period of lactation.
Itching, burning, tingling where the cream is applied, erythema, blisters, swelling, irritation and peeling of the skin. Allergic reactions (itching, urticaria).
The use of the cream in high doses does not cause any life-threatening reactions or conditions.
It should not be used in the first trimester of pregnancy (adequate and strictly controlled studies have not been conducted). When intravaginal use in women in the second and third trimesters of pregnancy no adverse effects on the fetus have been found, but the use of a vaginal applicator is undesirable.
With caution – during breast-feeding (it is unknown whether clotrimazole penetrates into breast milk).
Candide, Clotrimazol-Acrihin, Clotrimazol, Clotrimazol-Teva
|Conditions of storage|
At a temperature below 25°, out of the reach of children.
C.O. Hyperion SA, Romania
C.O. Hyperion SA
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