Claritrosin, tablets 250 mg, 10 pcs.

Indications

Clarithromycin is indicated for the treatment of infectious diseases caused by susceptible microorganisms. These diseases include:

Pharmacological effect

Antibiotic, macrolide

Special instructions

In the presence of chronic liver diseases, it is necessary to regularly monitor serum enzymes. Prescribe with caution against the background of drugs metabolized by the liver (it is recommended to measure their concentration in the blood). In the case of co-prescription with warfarin or other indirect anticoagulants, it is necessary to monitor the prothrombin time.

Active ingredient

Clarithromycin

Composition

Active substance:

Pregnancy

The use of the drug during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

Contraindications

Clarithromycin is contraindicated in patients with hypersensitivity to macrolide antibiotics. When treating with clarithromycin, do not prescribe ergot derivatives.

Side Effects

The most common complaints are from the gastrointestinal tract (nausea, dyspepsia, abdominal pain, vomiting and diarrhea). Moderate to life-threatening pseudomembranous colitis has been reported.
Other adverse reactions include headaches, taste disturbances, and transient increases in liver enzymes. There are reports of rare cases of parasthesia.

Interaction

When taken simultaneously, it increases the concentration in the blood of drugs metabolized in the liver with the help of cytochrome P450 enzymes – indirect anticoagulants, carbamazepine, theophylline, astemizole, cisapride, terfenadine (2-3 times), triazolam, midazolam, cyclosporine, disopyramide, phenytoin, rifabutin, lovastatin, digoxin, ergot alkaloids, etc. Rare cases of acute necrosis of skeletal muscles have been reported, coinciding with the simultaneous administration of clarithromycin and hydroxymethylglutaryl-CoA reductase inhibitors – lovastatin and simvastatin.

Overdose

The development of symptoms from the gastrointestinal tract (nausea, vomiting, diarrhea) is likely; headache, confusion. In case of overdose, immediate gastric lavage and symptomatic treatment are necessary.

Clinical pharmacology

Macrolide bacteriostatic antibiotic of the second generation from the group of broad-spectrum macrolides. Disturbs the protein synthesis of microorganisms (binds to the 50S subunit of the ribosomal membrane of the microbial cell). Active against: Streptococcus agalactiae (Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae), Haemophilus influenzae (parainfluenzae), Haemophilus ducreyi, Neisseria donorrhoeae, Neisseria meningitidis, Listeria monocytogenes, Legionella pneumophila, Mycoplasma pneumoniae, Helicobacter (Campilobacter) pylori, Campilobacter jejuni, Chamidia pneumoniae (trachomastis), Moraxella (Branhamella) catarrhalis, Bordetella pertussis, Propionibacterium acnes, Mycobacterium avium, Mycobacterium leprae, Staphylococcus aureus, Ureaplasma urealyticum, Toxoplasma gondii, Corynebacterium spp., Borrelia burgdorferi, Pasteurlla multocida, some anaerobes (Eubacterium spp., Peptococcus spp., Propionibacterium spp., Clostridium perfringens, Bacteroides melaninogenicus) and all mycobacteria except M. tuberculosis.

Pharmacokinetics

Storage conditions

List B. In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life

2 years. Do not use after the expiration date indicated on the package.

Manufacturer

Sintez, Russia