Candide, vaginal gel 2% 30 g
€3.89 €3.46
Pharmacological action – antifungal topical.
Pharmacodynamics
Antimycotic effect of clotrimazole is associated with disruption of ergosterol synthesis, which is part of the cell membrane of fungi, which changes the membrane permeability and causes subsequent cell lysis. In low concentrations it is fungistatic and in high concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations it interacts with mitochondrial and peroxidase enzymes resulting in increase of hydrogen peroxide concentration to toxic level, which also promotes fungus cell destruction.
Effective against dermatophytes, yeast-like and mold fungi as well as Pityriasis versicolor and erythrasma pathogen. It has antimicrobial action against Gram-positive (staphylococcus, streptococcus) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis) as well as against Trichomonas vaginalis.
Pharmacokinetics
When clotrimazole is administered intravaginally, absorption is 3-10% of the administered dose. High concentrations in vaginal secretion and low concentrations in blood persist for 48-72 hours. In the liver it is quickly metabolized to inactive metabolites.
Indications
- genital infections caused by yeast-like fungi of the genus Candida and/or Trichomonas vaginalis (candidal vulvovaginitis, trichomoniasis);
- genital superinfections caused by clotrimazole-sensitive microorganisms.
Active ingredient
Clotrimazole
Composition
1 g of the gel contains:
The active ingredient:
Clotrimazole 20 mg;
Associates:
Cetyl alcohol;
Propylene glycol, glycerol;
Benzyl alcohol;
Cetomacrogol emulsion wax;
Carbopol 940 (carbomer 940);
Sodium hydroxide;
Chlorocresol;
Purified water.
How to take, the dosage
Topically.
It is administered intravaginally, in the position “lying on the back” with slightly bent legs. One full applicator of gel (about 5 g of the drug), once a day, in the evening. The course of treatment is 6 days. Repeated course of treatment is possible after consultation with a doctor.
Interaction
When administered vaginally, clotrimazole reduces the activity of amphotericin B and other polyene antibiotics.
When used simultaneously with natamycin and nystatin, clotrimazole activity may decrease.
Special Instructions
To prevent urogenital reinfection it is necessary to simultaneously treat the sexual partners.
In case of trichomoniasis for more successful treatment together with Candida other drugs with systemic action should be used (for example, metronidazole – orally).
During pregnancy the treatment with vaginal gel should be performed without applicator.
In patients with hepatic insufficiency the functional state of the liver should be periodically checked.
In case of signs of hypersensitivity or irritation the treatment is stopped.
Avoid contact of the drug with the mucous membrane of the eyes.
Do not use the drug during menstruation.
In the absence of the effect within 4 weeks the diagnosis should be confirmed.
Synopsis
A homogeneous gel of white color.
Contraindications
- high sensitivity to clotrimazole or excipients;
- menstrual period;
- pregnancy (first trimester).
With caution:
period of breastfeeding.
.
Side effects
Itching, burning, hyperemia and swelling of the vaginal mucosa, headache, gastralgia, frequent urination, intercurrent cystitis, burning sensation in the penis of the sexual partner, pain during sexual intercourse.
Overdose
The use of the drug in high doses does not cause any reactions or life-threatening conditions.
Pregnancy use
Clinical and experimental studies have not established that the use of the drug during pregnancy or during breastfeeding has adverse effects on the health of the woman or the fetus (child). However, the appropriateness of prescribing the drug should be decided individually after consultation with a physician.
Similarities
Candide, Clotrimazol-Acrihin, Clotrimazol, Clotrimazol-Teva
Weight | 0.050 kg |
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Shelf life | 3 years Do not use after the expiration date stated on the package. |
Conditions of storage | In the dark place at temperatures not exceeding 25 °C (do not freeze) Keep out of reach of children. |
Manufacturer | Glenmark Pharmaceuticals Ltd, India |
Medication form | vaginal gel |
Brand | Glenmark Pharmaceuticals Ltd |
Other forms…
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