Butadion, ointment 5% 20 g

Pharmgroup:

NSAIDs.

Pharmacological action:

A nonsteroidal anti-inflammatory drug with anti-inflammatory and analgesic effect. Indiscriminately inhibits the activity of cyclooxygenases (COX-1 and COX-2) and inhibits the synthesis of prostaglandins.

Phenylbutazone inhibits the synthesis of ATP-dependent mucopolysaccharides.

Butadione is used to relieve pain syndrome and reduce swelling associated with inflammation. When applied topically, it causes alleviation or disappearance of joint pain at rest and during movement. It reduces morning stiffness and swelling of the joints and increases the range of motion.

Indications

Post-traumatic inflammation of soft tissues and joints, for example, as a result of sprains, strains and bruises.
Rheumatic diseases of soft tissues (tenosynovitis, bursitis, damage to periarticular tissues), muscle pain of rheumatic and non-rheumatic origin.
Pain and swelling associated with diseases of the muscles and joints.
Rheumatoid arthritis.
Osteoarthritis.
Radiculitis.
Lumbago.
Sciatica.

Pharmacological effect

Pharmaceutical group:

NSAIDs.

Pharmaceutical action:

A nonsteroidal anti-inflammatory drug that has anti-inflammatory and analgesic effects. Indiscriminately inhibits the activity of cyclooxygenases (COX-1 and COX-2) and inhibits the synthesis of prostaglandins.

Phenylbutazone inhibits the synthesis of ATP-dependent mucopolysaccharides.

Butadione is used to eliminate pain and reduce swelling associated with the inflammatory process. When applied topically, it causes a weakening or disappearance of joint pain at rest and during movement. Reduces morning stiffness and swelling of joints, helps increase range of motion.

Special instructions

If skin redness occurs, therapy should be discontinued.

The ointment should be applied only to intact skin, avoiding contact with open wounds. After application, do not apply an occlusive dressing. The drug should not come into contact with the eyes and mucous membranes.

The drug should not be used to treat thrombophlebitis of the deep veins of the extremities. To prevent photosensitivity, protect the skin from direct sunlight. When used together with other dosage forms of Butadione, the maximum daily dose of this drug should be taken into account.

Impact on the ability to drive vehicles and operate machinery

Data on the effect of Butadion on the ability to drive a car and engage in other activities that require concentration and speed of psychomotor reactions are not provided.

Active ingredient

Phenylbutazone

Composition

1 g ointment contains:

Active substance:

phenylbutazone 50 mg.

Excipients:

methyl parahydroxybenzoate,

sodium carboxymethylcellulose,

colloidal silicon dioxide,

polysorbate 60,

glycerol 85%,

propylene glycol,

liquid paraffin,

purified water.

Pregnancy

The drug is contraindicated in the first and third trimesters of pregnancy due to the possibility of fetal developmental disorders.

In the second trimester of pregnancy, the use of Butadion is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use the drug during lactation, it is recommended to stop breastfeeding.

Contraindications

History of an attack of bronchial obstruction, allergic rhinitis, urticaria after taking acetylsalicylic acid or another NSAID.
I and III trimesters of pregnancy.
Breastfeeding period.
Violation of the integrity of the skin at the site of intended application.
Children’s age up to 14 years.
Combined use with other drugs containing phenylbutazone.
Hypersensitivity to phenylbutazone or other components of the drug, to acetylsalicylic acid and other NSAIDs.

Side Effects

Local reactions: eczema, photosensitivity, contact dermatitis (itching, redness, swelling of the treated skin area; papules, vesicles, peeling.

Allergic reactions: urticaria, angioedema, bronchospasm, generalized skin rash.

Interaction

No clinically significant interaction of the drug Butadione with other drugs has been established.

The combined use of Butadione with other NSAIDs should be avoided.

Butadione may enhance the effect of drugs that cause photosensitivity.

Overdose

The extremely low absorption of the active components of the drug when used externally makes overdose almost impossible.

Symptoms: if large quantities of ointment (more than 20 g) are accidentally ingested, systemic adverse reactions characteristic of NSAIDs may occur.

Treatment: gastric lavage and activated charcoal are required.

Storage conditions

Store at a temperature of 8 to 15 °C out of the reach of children.

Shelf life

5 years.

Manufacturer

Gedeon Richter, Hungary