Antitumor agent. It is a selective non-steroidal aromatase inhibitor. In postmenopause estradiol is mainly formed from estrone, which is produced in peripheral tissues by conversion from androstenedione (with the participation of aromatase enzyme). Reducing circulating estradiol levels has a therapeutic effect in women with breast cancer. In postmenopause, anastrozole at a daily dose of 1 mg causes a decrease in estradiol levels by 80%. Anastrozole has no progestogenic, androgenic and estrogenic activity; in therapeutic doses it does not affect cortisol and aldosterone secretion.
Cancer, NoBreast Cancer in Postmenopause.
White, round, biconvex, film-coated tablets with “ANA 1” engraved on one side of the tablet; white or almost white on the fracture.
sodium carboxymethyl starch,
Opadray white (macrogol 400, hypromellose, titanium dioxide).
How to take, the dosage
Orally – 1 mg once a day.
Anastrozole reduces the effectiveness of estrogens.
Clinical studies have shown that simultaneous use of anastrozole with antipyrine and cimetidine drug interaction due to induction of microsomal liver enzymes is unlikely.
If the hormonal status of the patient is uncertain, the menopausal state should be confirmed by additional biochemical studies.
The safety of anastrozole administration in patients with moderate liver function abnormalities has not been established.
Anastrozole should not be used concomitantly with estrogens.
Effect on driving and operating machinery
During treatment, do not perform work requiring high concentration and rapid psychomotor reactions.
Premenopause, severe renal insufficiency (CKR less than 20 ml/min), moderate and severe hepatic insufficiency, pregnancy, lactation, childhood, hypersensitivity to anastrozole.
Endocrine system: “hot flashes”, vaginal dryness and thinning of hair.
Digestive system: anorexia, nausea, vomiting, diarrhea. In patients with advanced breast cancer, in most cases with metastases to the liver, elevated levels of GGT and rarely – alkaline phosphate were noted.
CNS: asthenia, somnolence, headache.
Metabolism: a slight increase in total cholesterol.
Allergic reactions: skin rash.
Sinton Spain S.L., Spain
Sinton Spain S.L.
Buy Anazales, 1 mg 28 pcs. with delivery to USA, UK, Europe and over 120 other countries.