Amlodipine-Vertex, tablets 5 mg 60 pcs

Amlodipine is a class II selective calcium channel blocker. Antihypertensive effect is due to direct relaxing effect on vascular smooth muscles.

It is assumed that antianginal action of amlodipine is related to its ability to dilate peripheral arterioles; it leads to decrease of ROP, reflex tachycardia does not occur.

The result is a decrease in myocardial oxygen demand and energy consumption by the heart muscle.

On the other hand, amlodipine appears to cause dilation of the large caliber coronary arteries and coronary arterioles of both intact and ischemic areas of myocardium. This ensures the flow of oxygen to the myocardium during coronary artery spasms.

Indications

Hypertension (high blood pressure), Edema, Heart pain, Blood pressure, Angina

Arterial hypertension (including in combination therapy), stable angina, unstable angina (including Prinzmetal angina)

Active ingredient

Amlodipine

Composition

Tablets

1 tablet contains amlodipine (in bezilate form) 5 mg

How to take, the dosage

In adults, when taken orally, the initial dose is 5 mg once daily.

The dose can be increased if necessary.

Maximum dose:when taken orally is 10 mg/day.

Interaction

With the simultaneous use of Amlodipine with other antihypertensive drugs may increase the hypotensive effect;

with agents for inhalation anesthesia – possible increase in hypotensive effect;

with lithium preparations – possible manifestations of neurotoxicity, including nausea, vomiting, diarrhea, ataxia and/or tinnitus.nausea, vomiting, diarrhea, ataxia, tremor and/or tinnitus;

with sympathomimetics – possible decrease of hypotensive effect.

Indomethacin and other NSAIDs may decrease the hypotensive effect of amlodipine by inhibiting the synthesis of prostaglandins in the kidneys and/or causing fluid retention.

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Special Instructions

Amlodipine with caution is used in patients with hepatic impairment, aortic stenosis, chronic heart failure.

Patients with impaired renal function and elderly patients do not require dose reduction.

Amlodipine may be used to treat patients with dilated (non-ischemic) cardiomyopathy accompanied by severe chronic heart failure.

There are no clinical data on the use of amlodipine in children.

Contraindications

Severe arterial hypotension.

Hypersensitivity to dihydropyridine derivatives.

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Side effects

Cardiovascular system disorders:peripheral edema, palpitation, skin hyperemia are possible; with high doses – arterial hypotension, arrhythmias, shortness of breath.

Digestive system disorders:nausea, abdominal pain; rarely – gum hyperplasia.

CNS side:possible headache, fatigue, drowsiness, dizziness.

Allergic reactions:skin rash, itching.

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Pregnancy use

The safety of Amlodipine administration during pregnancy and lactation has not been established.

The use is possible only in cases when the estimated benefit to the mother exceeds the potential risk to the fetus or child.

Similarities

Norvasc, Amlodipine-Teva, Normodipine, Kalchek, Cardilopine, Amlodipine, Amlorus, Amlotop, Amlodipine-Teva